An observational study in Gestational Diabetes Mellitus, sponsored by Peking Union Medical College Hospital. Status unknown. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2017-08-11.
Sponsored by Peking Union Medical College Hospital · Observational
Gestational diabetes mellitus (GDM) has many adverse effects on pregnant women and fetuses. At present, no prediction marker for GDM in early pregnancy is accepted. There is still a lack of recognized early predictors. This study was designed to identity valuable biomarkers for GDM.This was a prospective observed cohort study. 140 pregnant women were recruited in early pregnancy, and followed up to 6 weeks postpartum. Glucose challenge test and 75g oral glucose tolerance test were performed after 24 weeks of pregnancy, and GDM was diagnosed according to the latest ADA standard. Urinary samples were collected in the first (\<12 weeks), second (24\~28 weeks) and third (32\~weeks) trimester of pregnancy. Urinary proteomics and metabolomics were analyzed by ultra-performance liquid chromatography tandem mass spectrometry. 15 cases of GDM women and 50 cases of control women were used for longitudinal analysis; 15 cases of GDM women and 15 cases of age matched control women were used for difference analysis.
842 studies on the registry are indexed under Diabetes, Gestational; 198 are open to participants now.
This study's enrollment of 140 is below the median of 200 across 269 observational studies indexed under Diabetes, Gestational.
Browse Diabetes, Gestational studies →Peking Union Medical College Hospital is the lead sponsor of 1,115 studies on the registry; 463 are open to participants now.
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Pregnant women were recruited in early pregnancy, and followed up to 6 weeks postpartum
-Pregnant women （\<12 weeks）
Exclusion Criteria:
Those women were diagnosed as gestational diabetes mellitus
Other: lifestyle intervention or insulin treatment
Those women were diagnosed without gestational diabetes mellitus
Firstly，the gestational diabetes mellitus（GDM） women were treated with lifestyle intervention.Those women were treated with insulin if their blood glucose was not well Controled.
Urinary samples were analyzed
Urinary samples were collected and urinary proteomics and metabolomics were analyzed by ultra-performance liquid chromatography tandem mass spectrometry.
Time frame: in the first (<12 weeks) trimester of pregnancy
Urinary samples were analyzed
Urinary samples were collected and urinary proteomics and metabolomics were analyzed by ultra-performance liquid chromatography tandem mass spectrometry.
Time frame: in the second (24-28 weeks) trimester of pregnancy
Urinary samples were analyzed
Urinary samples were collected and urinary proteomics and metabolomics were analyzed by ultra-performance liquid chromatography tandem mass spectrometry.
Time frame: in the third (>32 weeks) trimester of pregnancy
No study locations are listed for this record.
This study is status unknown, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.
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Peking Union Medical College Hospital