An interventional study of NIPPV and NCPAP in Nasal Intermittent Positive Pressure Ventilation and Nasal Continuous Positive Airway Pressure, sponsored by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University. Status unknown at 1 site in China. Open to participants aged 5 Minutes to 6 Hours. Per ClinicalTrials.gov, last updated 2017-07-24.
Sponsored by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Not applicable, Interventional, and Treatment
In the past, several studies have compared the effects between nasal intermittent positive pressure ventilation(NIPPV) and nasal continuous positive airway pressure(NCPAP) on the incidence of intubation in preterm infants, and the results were inconsistent.The purpose of the present study was to compare NIPPV with NCPAP on the need for endotracheal ventilation and subsequent complications
To this day, early use of noninvasive respiratory support strategies has been suggested to be the most effective pathway to reduce those risks. Nasal continuous positive airway pressure (NCPAP) and nasal intermittent positive pressure ventilation (NIPPV) are two widely used ways of noninvasive ventilation strategies in preterm infant. As compared with invasive ventilation, NCPAP reduces the risks abnormal neurodevelopment. However, there is only 60% success rate of avoiding intubation in the preterm neonate supported with NCPAP. Supplying with an intermittent peak pressure on NCPAP, NIPPV is considered as a strengthened version of NCPAP with increased flow delivery in the upper airway, increased minute volume and functional residual capacity and recruitment of collapsed alveoli, improved stability of the chest wall and reduced asynchrony of thoraco-abdominal movement,which have been proven to be crucial to decrease the incidences of invasive ventilation and death. However, studies have compared the effects between nasal intermittent positive pressure ventilation(NIPPV) and nasal continuous positive airway pressure(NCPAP) on the incidence of intubation in preterm infants, and the results were inconsistent.
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University is the lead sponsor of 120 studies on the registry; 42 are open to participants now.
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Exclusion Criteria:
NIPPV is used as a primary mode of ventilation in premature infants with respiratory distress syndrome
Device: NIPPV
NCPAP is used as a primary mode of ventilation in premature infants with respiratory distress syndrome
Device: NCPAP
NIPPV is used as a primary mode of ventilation in premature infants with respiratory distress syndrome
NCPAP is used as a primary mode of ventilation in premature infants with respiratory distress syndrome
intubation rate
the infant is intubated ventilation
Time frame: within 7 days
Intraventricular hemorrhage
the incidence of intraventricular hemorrhage
Time frame: within 28 days
bronchopulmonary dysplasia
bronchopulmonary dysplasia was defined according to the National Institutes of Health consensus definition
Time frame: at a post-menstrual age of 36 weeks or at discharge
Bayley Scales of Infant Development
scores of Bayley Scales of Infant Development
Time frame: at 2 months old and 2 years old
Neonatal necrotizing enterocolitis(NEC)
the incidence of neonatal necrotizing enterocolitis(\>stage II);for NEC, Bell staging will be used
Time frame: within 7 days
Plan to share: Undecided
No publications or documents are linked to this record.
Start is estimated for Aug 2017; primary completion for Jul 2020, 35 months later.
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This study is status unknown, as verified in Jun 2017. You cannot join it, but the record below documents what was studied.
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Daping Hospital and the Research Institute of Surgery of the Third Military Medical University →