An observational study in Chronic Obstructive Pulmonary, sponsored by University Hospital, Montpellier. Completed at 1 site in France. Open to participants aged 35 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-04-18.
Sponsored by University Hospital, Montpellier · Observational
Chronic Obstructive Pulmonary Patients is a defined by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. It is associated with an atrophy of the skeletal muscle that impairs the patient's prognosis. The biological mechanisms of this muscle atrophy have not been elucidated, and the "spill-over theory" has recently emerged. Indeed, in COPD patients, the pulmonary inflammation is associated with a systemic low-grade inflammation, and the increased pro-inflamatory molelcules in the blood - which constitute the cellular micro-environement of the muscle fibre - could activate the mechanisms of the cell atrophy.
University Hospital, Montpellier is the lead sponsor of 1,244 studies on the registry; 225 are open to participants now.
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Chronic Obstructive Pulmonary Patients
35 to 85 years old
Exclusion Criteria:
Determination of pro-inflammatory plasma factors at Healthy subjects aged from 35 to 85 years old
Other: Determination of pro-inflammatory plasma factors
Determination of pro-inflammatory plasma factors at COPD patients aged from 35 to 85 years old
Other: Determination of pro-inflammatory plasma factors
Determination of pro-inflammatory plasma factors at COPD patients aged from 35 to 85 years old and Healthy subjects aged from 35 to 85 years old
Myotube diameter of in vitro cultured myotubes
Myotube diameter of in vitro cultured myotubes from healthy subjects, exposed to the serum of healthy controls and COPD patients
Time frame: 6 days
Expression and translation of markers of
Expression and translation of markers of anabolic and catabolic pathways
Time frame: 6 days
Level of pro-Inflamatory markers
Level of pro-Inflamatory markers in the serum
Time frame: 6 days
Plan to share: Undecided — NC
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This study is completed, as verified in Sep 2018. You cannot join it, but the record below documents what was studied.
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University Hospital, Montpellier