An interventional study of ovarian tissue biopsy in Childhood Cancer and Fertility Disorders, sponsored by Gumy-Pause Fabienne. Active, not recruiting at 2 sites in Switzerland. Open to female participants aged 2 Months to 18 Years. Per ClinicalTrials.gov, last updated 2026-05-27.
Sponsored by Gumy-Pause Fabienne · Not applicable, Interventional, and Prevention
Background:
Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients. Unfortunately, cancer treatments can be harmful to the gonads and can affect reproductive and endocrine functions. While loss of fertility is a major concern for most patients, only the experimental option of ovarian tissue cryopreservation can be proposed to prepubertal girls with a high risk of infertility. For pubertal patient, cryopreservation of mature oocytes after ovarian stimulation can be offered if oncological treatment debut can be delayed. As it is often not possible, ovarian tissue cryopreservation can also be offered.
Primary aims
- To cryopreserve ovarian tissue of pre or peripubertal patient who will be receiving highly gonadotoxic oncological treatment.
Secondary aims
Multicentric study: HUG, CHUV
9,365 studies on the registry are indexed under Neoplasms; 2,489 are open to participants now.
This study's planned enrollment of 100 is above the median of 50 across 7,253 interventional studies indexed under Neoplasms.
Browse Neoplasms studies →Gumy-Pause Fabienne is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Procedure: ovarian tissue biopsy
ovarian tissue biopsy during general anesthesia
Number of pediatric cancer patient who will undergo ovarian tissue cryopreservation for fertility preservation
Time frame: 0-20 years
Incidence of complications related to the ovarian biopsy (safety)
The safety will be assessed by recording the number of complications of the procedure (e.g. bleeding, infection)
Time frame: 0-20 years
Comparison of biochemical markers
Comparison of biochemical markers (e.g., FSH; LH, AMH, progesterone, oestradiol) between patients who undergo ovarian biopsy and controls
Time frame: 0-20 years
This study is active, not recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Gumy-Pause Fabienne