CClinicalTrials.gg
Status unknownNCT03172169Updated Jun 6, 2017

Specific Small RNA in Plasma for Predicting Diaphragm Dysfunction in Mechanically Ventilated Patients

An observational study in Mechanical Ventilation Complication, sponsored by Southeast University, China. Status unknown. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-06-06.

Sponsored by Southeast University, China · Observational

The sponsor has not verified this record recently (last verified Jun 2017), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
140
Ages
18 Years to 75 Years
Sex
All
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Study summary

Through the literature screening of MyomiRX 7, the detection of mechanical ventilation group, difficult withdrawal unit and healthy adult plasma levels of MyomiRX in the evaluation of function and skeletal muscle thickness of the diaphragm, the correlation analysis of 7 kinds of MyomiRX and diaphragmatic dysfunction. The research value of this project is to explore the predictive value of plasma MyomiRX level on diaphragmatic dysfunction in patients with mechanical ventilation, and to lay the foundation for finding the target of VIDD diagnosis and treatment

Read the detailed description
  1. research content (1) screening MyomiR through literature review (2) selection of mechanical ventilation group, difficult withdrawal units and three healthy adult groups, method for the detection of plasma MyomiRX level and clinical assessment of diaphragmatic function, observation of the relationship between MyomiRX level and diaphragmatic dysfunction, prediction of plasma MyomiRX levels in patients with mechanical ventilation for diaphragmatic dysfunction in value.
  2. research objectives Objective to investigate the predictive value of specific minute RNA in plasma muscle tissue on diaphragmatic dysfunction in mechanical ventilation patients Experimental grouping (1) the control group of mechanical ventilation (time of examination, preoperative, admission to ICU and before extubation); (2) difficulty in withdrawal of units (first days, third days and seventh days after the failure of the test time for the first withdrawal); (3) the healthy control group (after the test time was selected)
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Conditions studied

  • Mechanical Ventilation Complication
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In context

Lead sponsor

Southeast University, China is the lead sponsor of 164 studies on the registry; 44 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

healthy control group: healthy volunteers mechanical ventilation control group: patients who underwent elective cardiothoracic surgery after scheduled and controlled mechanical ventilation for more than 12h were transferred to ICU (including coronary artery bypass grafting and valve replacement) difficult weaning: difficult to diagnose patients in ICU (weaning time from mechanical ventilation for >48 hours and first SBT failure)

Inclusion criteria

healthy control group: healthy volunteers mechanical ventilation control group: patients who underwent elective cardiothoracic surgery after scheduled and controlled mechanical ventilation for more than 12h were transferred to ICU (including coronary artery bypass grafting and valve replacement) difficult weaning: difficult to diagnose patients in ICU (weaning time from mechanical ventilation for >48 hours and first SBT failure)

Exclusion criteria

Exclusion Criteria:

  1. severe respiratory depression, high paraplegia and neuromuscular lesions;
  2. esophageal obstruction, esophageal perforation, severe esophageal varices bleeding, upper gastrointestinal surgery and other reasons can not be placed EAdi catheter;
  3. thoracic deformity and diaphragmatic hernia;
  4. serious heart, liver, kidney and other organ failure, hemodynamic instability;
  5. pregnancy;
  6. the end of the tumor or the family member give up the active treatment
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
140 participants (estimated)
Target follow-up
3 Months
Patient registry
Yes

Groups and cohorts

  • Healthy control group

    no intervention

    Other: no Intervention

  • Difficult withdrawal group

    The mechanical ventilation time was \>48 hours and the first SBT failure

    Other: no Intervention

  • Mechanical ventilation control group

    Elective and expected postoperative control of mechanical ventilation time greater than 12h after cardiothoracic surgery

    Other: no Intervention

Interventions

  • Otherno Intervention

    no Intervention

06

What researchers measure

Primary outcomes

  1. Prediction of diaphragmatic dysfunction using RT-PCR microRNA level

    Prediction of diaphragmatic dysfunction in patients with mechanical ventilation by specific minute RNA of plasma muscle tissue

    Time frame: 7 days

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Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 6, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03172169
Lead sponsor
Southeast University, China
Responsible party
Chun Pan (Principal Investigator, Southeast University, China) — Principal investigator
First posted
Jun 1, 2017
Start date
Jun 15, 2017 (estimated)
Primary completion
Dec 1, 2017 (estimated)
Completion
Dec 1, 2017 (estimated)
Last update
Jun 6, 2017

Study contacts

xu xiaoting, master
Contact
xuxiaoting2005@163.com
+86 13645188041
pan chun, doctor
principal investigator · Colleague

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jun 2017. You cannot join it, but the record below documents what was studied.

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