An observational study in Vitamin D Deficiency, sponsored by Nancy Ahmed El Salmawy. Status unknown. Open to participants aged 2 Years to 5 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-06-07.
Sponsored by Nancy Ahmed El Salmawy · Observational
To detect the effect of vitamin D deficiency in the development of early childhood caries (ECC) among Egyptian children.
Justification for undertaking the trial:
American Academy of Pediatric Dentistry (2012), defined early childhood caries (ECC) as the presence of one or more decayed, missing teeth (resulting from caries), or filled surfaces in the primary tooth of child 6 years old or younger.
Early childhood caries is a chronic childhood disease, that decreasing quality of life, this include pain, disturbed sleep, poor aesthetics, difficulty in eating and speaking and behavioral changes that affect the child's self-esteem. (Guay, 2004).
Due to the rising incidence of dental carries in early childhood, contributory factors need to be investigated in order to facilitate treatment of such a large population of children in desperate need of dental care (Guay, 2004).These multiple risk factors include the lack of a dental home, poor oral hygiene, diet, and nutrition ( Najeeb et al., 2016).
Enamel is the most mineralized substance in the human body; it is mainly made of calcium and phosphate. Vitamin D plays an important role in increasing the absorption of calcium and phosphate from food. Which calcium and phosphate improve the strength of the teeth as make them able to fight the demineralization from bacteria (Youssef et al., 2011). Therefore, it is responsible of promoting the calcification of teeth, having a topical fluoride like effect, and in the forming of enamel, dentin, and bone. (Mellanby \& Pattison, 1928).
Vitamin D receptors are present on the cells of immune system and on the teeth. It binds to these receptors and increases the amount of good antimicrobial proteins as cathelicidin and other special defense in saliva (Youssef et al., 2011). These antimicrobial peptides have antibacterial neutralizing activity against periodonto pathogens as gram negative and gram positive bacteria and candida albicans, its effective in vitro against oral microorganisms such as streptococcus mutants, prophyromonas gingivalis and actinobacillus, so it prevents dental caries.( Potturu et al., 2014).
East, (1939) study concluded that children who consumed a high vitamin D diet, vitamin D played an indispensable role in 1) preventing the initiation of new caries, 2) inhibiting the spread of existing caries, and 3) arresting the caries. Likewise, an examination of children found a decreased caries prevalence in areas of increased vitamin D exposure.
772 studies on the registry are indexed under Vitamin D Deficiency; 61 are open to participants now.
This study's planned enrollment of 288 is above the median of 138 across 183 observational studies indexed under Vitamin D Deficiency.
Browse Vitamin D Deficiency studies →This is the only study on the registry with Nancy Ahmed El Salmawy as lead sponsor.
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Egyptain children age ranges from 2 to 5 years from Abo El Rish Hospital, Malnutrition clinic.
Exclusion Criteria:
1. children with vitamin D deficiency with age group from 2-5 years old
Prevalence of early childhood caries
Stages of Early childhood caries. 1. Initial (reversible stage) 2. Damaged (carious) stage 3. Deep lesions 4. Traumatic stage. 5. Arrested caries.
Time frame: 6 months
Delayed tooth formation and eruption
* Delayed tooth eruption. * Tooth smaller than normal
Time frame: 6 months
Gingivitis
binary yes or no
Time frame: 6 months
No study locations are listed for this record.
Plan to share: Undecided
This study is status unknown, as verified in Jun 2017. You cannot join it, but the record below documents what was studied.
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