An observational study in Lung Transplantation and Sleep-disordered Breathing, sponsored by Universitaire Ziekenhuizen KU Leuven. Recruiting at 1 site in Belgium. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-07-03.
Sponsored by Universitaire Ziekenhuizen KU Leuven · Observational
Sleep-disordered breathing (SDB) describes a group of disorders in which partial or complete cessation of breathing occurs many times throughout the night, resulting in daytime sleepiness or fatigue that interferes with a person's ability to function and reduces quality of life. Transplantation has become an important treatment modality for end-stage organ failure. Transplant recipients are now living longer and, hence, develop chronic adverse medical conditions. Furthermore, transplantation is associated with weight gain. Despite the high prevalence of poor sleep and cardiovascular conditions among transplant patients, SDB is not well studied in these patients.
The primary research objective is to evaluate the prevalence, incidence and type (central or obstructive) of SDB in patients after lung transplantation.
Secondary research objectives are the evaluation of correlations between severity of SDB and clinical findings (weight, medical therapy, heart function, lung function, renal function, graft failure, ...). Furthermore, the investigators will evaluate the relationship between SDB and cardiovascular morbidity.
1,092 studies on the registry are indexed under Respiratory Aspiration; 216 are open to participants now.
This study's planned enrollment of 300 is above the median of 65 across 184 observational studies indexed under Respiratory Aspiration.
Browse Respiratory Aspiration studies →Universitaire Ziekenhuizen KU Leuven is the lead sponsor of 928 studies on the registry; 261 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients 1 year after lung transplantation are systematically evaluated by polysomnography.
Exclusion Criteria:
Polysomnography at 1 year after lung transplantation.
Other: No intervention - Diagnostic polysomnography at 1 year after lung transplantation
Number of participants with SDB and type (central or obstructive) of SDB
Prevalence of different types of SDB after lung transplantation
Time frame: 1 year after lung transplantation
Echocardiography
Correlations between SDB and heart function
Time frame: 1 year after lung transplantation
Lung function measurement
Correlations between SDB and lung function
Time frame: 1 year after lung transplantation
Blood analysis
Correlations between SDB and renal function
Time frame: 1 year after lung transplantation
24h blood pressure
Evaluation of relationship between hypertension and SDB
Time frame: 1 year after lung transplantation
Plan to share: No
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Universitaire Ziekenhuizen KU Leuven