An observational study in Non-small Cell Lung Carcinoma, sponsored by University of Paris 5 - Rene Descartes. Completed at 1 site in France. Open to participants aged 18 Years to 95 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-05-08.
Sponsored by University of Paris 5 - Rene Descartes · Observational
Aging and cancer are two conditions associated with extensive metabolic changes that can cause malnutrition. However, the clinical features and the underlying mechanisms leading to malnutrition are different in these two cases. We therefore wonder how age can influence the metabolic response to cancer.
During aging, among other physiological modifications, inactivity and insulin resistance cause a progressive muscle loss associated with a decrease in resting energy expenditure (REE). In cancer, loud inflammation background also provokes a decrease in muscle mass as well as in fat mass. However, previous studies reported an increased REE, termed hypermetabolism, probably linked to inflammation.
Data concerning response to aggression in the elderly patient is scarce and even inexistent when it comes to cancer. The investigators hypothesize that the mitochondrial dysfunction that comes with aging and that decreases the ATP rendering per unit of energy-producing nutrient oxidized increases the amount of nutrient to be consumed in order to sustain to energy needs. Therefore, in this situation, elderly patients could have a higher rate or degree of hypermetabolism than younger patients.
The primary objective of this study is to assess the effect of aging on the metabolic response to cancer assessed by resting energy expenditure measured by indirect calorimetry corrected by whole body fat free mass calculated from single slice CT imaging at the third lumbar vertebra.
The secondary objective of this study is to point out some inflammatory or endocrine determinants of these energy metabolism changes in the cancer patient.
Non-small cell lung carcinoma seems to be a relevant choice for this study because it is frequently associated with cachexia and the literature reports a high rate of hypermetabolism in this cancer.
6,485 studies on the registry are indexed under Carcinoma, Non-Small-Cell Lung; 1,630 are open to participants now.
This study's enrollment of 27 is below the median of 161 across 948 observational studies indexed under Carcinoma, Non-Small-Cell Lung.
Browse Carcinoma, Non-Small-Cell Lung studies →University of Paris 5 - Rene Descartes is the lead sponsor of 17 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
The population is selected from the patients coming for their one-day pre-treatment evaluation at the oncology ward of the Cochin Hospital.
Exclusion Criteria:
Patients with non-small cell lung carcinoma younger than 75y
Patients with non-small cell lung carcinoma aged 75 or more
Measured resting energy expenditure (mREE) in kilocalorie per day
Energy expenditure is measured by indirect calorimetry.
Time frame: Day 0
Blood C-Reactive Protein in milligram per milliliter
Inflammatory status
Time frame: Day 0
Blood Interleukine-6 in picogram per milliliter
Inflammatory status
Time frame: Day 0
Blood Tumor Necrosis Factor alpha in picogram per milliliter
Inflammatory status
Time frame: Day 0
Blood Insulin in milliunit per liter
Endocrine Status - Glucose Homeostasis
Time frame: Day 0
Blood ultra-sensitive Thyroid Stimulating Hormone in milliunit per liter
Endocrine Status - Thyroid Function
Time frame: Day 0
Blood Insulin-like Growth Factor 1 in nanogram per liter
Endocrine Status - Somatotropic axis
Time frame: Day 0
Blood Glucose in millimole per liter
Endocrine Status
Time frame: Day 0
Homeostasis Model assessment of Insulin resistance
Aggregates blood Insulin and glucose level as an insulin resistance score
Time frame: Day 0
Lean Body Mass in kilogram
Estimated from muscular area at the third lombular vertebra from CT-scan
Time frame: Day 0
energy intake in kilocalorie per day
Estimated by a qualified dietetican
Time frame: Day 0
Albumin in gram per liter
Nutritional Satus
Time frame: Day 0
Transthyretin in gram per liter
Nutritional Satus
Time frame: Day 0
Predicted resting energy expenditure (HB) in kilocalorie per day
REE estimated with Harris \& Benedict Formula
Time frame: Day 0
Percentage of estimated energy expenditure
Percentage of HB : (mREE/HB) x 100
Time frame: Day 0
Plan to share: No
This study is completed, as verified in May 2017. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Carcinoma, Non-Small-Cell Lung→
University of Paris 5 - Rene Descartes