An observational study in Obesity, sponsored by Baylor College of Medicine. Completed at 1 site in United States. Open to participants aged 7 Years to 15 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-04-18.
Sponsored by Baylor College of Medicine · Observational
In this study the investigators will interrogate an existing data set to examine whether genetic variants contribute to an inverse association between weight status and cognitive function. Investigators hypothesize that body mass index (BMI) will be inversely related to a number of variables measuring cognitive function, and that that this inverse relation will be at least partially attributable to genetic variants which influence both BMI and cognition.
Investigators will use existing data collected as part of the Texas Twin Project (TTP). TTP collected neuropsychological task data on cognition (executive functioning and general cognitive abilities) from a computerized test battery, as well as BMI data, on a sample of 869 twins. Investigators will use information from the known extent of genetic and environmental sharing between members of MZ (monozygotic; identical) and DZ (dizygotic; fraternal) twin pairs to quantify the genetic correlation between measures of cognition and BMI using biometric genetic modeling under the assumptions of the classical twin model. The specific aims are:
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's enrollment of 869 is above the median of 135 across 1,283 observational studies indexed under Obesity.
Browse Obesity studies →Baylor College of Medicine is the lead sponsor of 734 studies on the registry; 110 are open to participants now.
Of its 83 completed or terminated interventional studies of FDA-regulated products, 44 (53%) have results posted.
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Individuals from the Texas twin Project dataset, who were twins and higher-order multiples previously recruited from the Houston and Austin Metropolitan areas, via flyers, the internet (study website) and contact through public school rosters
All participants in the TTP database with executive functioning and BMI data, without a parent-reported medical disorder affecting growth
Exclusion Criteria:
Parent-reported medical disorder affecting growth More than one sibling in the dataset (if triplets are present, only two randomly selecting siblings will be included).
Executive functioning
This measure will be derived from a computerized test battery incorporating the Animal Stroop, Stop Signal, Mickey (an anti- Trail Making, Local-Global, Plus-Minus, Digit Span Backward, Symmetry Span, Listening Recall, 2-Back, Keeping Track, and Running Memory for Letters tasks. A latent factor of variance common to all these tasks will be used to indicate "higher order executive functioning".
Time frame: 2 hours
Body mass index
Heights and weights were measured by trained study personnel and BMI will be calculated as weight in kilograms (kg) divided by height in centimeters (cm) squared.
Time frame: 10 minutes
General Cognitive Ability
This was assessed using the WASI-II
Time frame: 1 hour
Academic Achievement
This was assessed using the Woodcock-Johnson-III Calculations and Passage Comprehension tests
Time frame: 30 minutes
Plan to share: No — This protocol involves secondary data analysis of existing studies. Data will not be shared with other investigators since they should obtain data from the primary sources.
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This study is completed, as verified in Apr 2017. You cannot join it, but the record below documents what was studied.
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Baylor College of Medicine