An observational study in Cognitive Function and Healthy, sponsored by Lance Johnson. Completed at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2020-07-23.
Sponsored by Lance Johnson · Observational
Impaired metabolism and the gene apolipoprotein E (ApoE) are independent risk factors for cognitive impairment and dementia. In humans, there are three major versions of apoE (E): E2, E3, and E4. Some studies suggest that the different versions of apoE have varying effects on whole body and brain metabolism. The goal of this project is to better understand the relationship between apoE and metabolism. This will help investigators identify new targets for the prevention and treatment of cognitive decline and dementia.
The investigator hopes determine whether a participant's version of ApoE affects their metabolic rate at rest and during a cognitive challenge. To determine this, the investigator will measure basal (resting) metabolic rates using a technique called indirect calorimetry (IC). This is accomplished by wearing a loose-fitting face mask that measures oxygen intake and carbon dioxide output.
To more accurately measure the amount of carbohydrates, fats and proteins that the body is metabolizing, participants will be asked to provide two urine samples (one at the beginning, and one at the end, of the study).
To determine what version of ApoE the participant inherited, the investigator will conduct a genetic test on DNA isolated from the participant's blood.
This is the only study on the registry with Lance Johnson as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Cognitively normal and are in good overall health.
Exclusion Criteria:
The investigator will measure the amount of oxygen participants breathe in and the amount of carbon dioxide they breathe out using a portable unit. Participants will be asked wearing a loose-fitting face mask that measures oxygen intake and carbon dioxide output.
The investigator will conduct a genetic test on DNA isolated from from the participants blood. Participants will be asked to provide about 2 tablespoons.
To more accurately measure the amount of carbohydrates, fats and proteins that the participants bodies metabolize, participants will be asked to provide two urine samples (one at the beginning, and one at the end, of the study). The total amount of urine to be collected is approximately 4 teaspoons.
Participants will be asked to follow simple instructions that are displayed on computer screen.
Indirect Calorimetry
Measure resting state respiratory quotient in cognitively normal participants with various ApoE genotypes
Time frame: 4 hours
Respiratory Quotient (RQ)
Measure RQ during a cognitive challenge in cognitively normal individuals with various ApoE genotypes
Time frame: 4 hours
Urea Nitrogen Output
Improve RQ measure accuracy by determining urinary urea nitrogen output in collected urine samples from these subjects.
Time frame: 4 hours
Genotype
Genotype subjects using DNA isolated from collected blood samples.
Time frame: 4 hours
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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