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CompletedNCT03094962Updated Nov 15, 2018

Development of a Musculoskeletal Model of the PIP Joint

An interventional study of Motion capture and MR scan in Patient Specific Computational Modeling, sponsored by University of Southampton. Completed at 1 site in United Kingdom. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-11-15.

Sponsored by University of Southampton · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 2 years 1 month after the study started (first participant enrolled Jan 2015, registered Mar 2017).
Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

The proximal interphalangeal (PIP) joint is the second joint in the finger from the finger tip. The outcome following replacement surgery of this joint is considered unsatisfactory. In order to improve these outcomes, it would be helpful to understand the geometry of the joint, how it moves and the forces that are involved. This can be achieved using computer models that model the bones and the soft tissues - musculoskeletal models. In order to make these models as representative as possible, they should be generated using anatomical data.

Data will initially be extracted from patients' existing magnetic resonance imaging (MRI) and computed tomography (CT) scans. This will enable the computer model to begin being constructed. In parallel to the model initialisation, anatomical and motion data of the PIP joint of healthy volunteers will be collected. The necessary data will be collected using CT and MRI scans, as well as optical motion tracking methods. These data will then be used to populate the musculoskeletal model.

Once the model is constructed, it will be used to simulate the motion of the joint and look at the effect of a simulated PIP joint replacement. This information should then provide insight as to how PIP joint replacements might be improved in future.

02

Conditions studied

  • Patient Specific Computational Modeling

Keywords

  • Kinematics
  • MRI Scans
  • CT Scan, Single-Photon Emission
  • finger interphalangeal joint
03

In context

Lead sponsor

University of Southampton is the lead sponsor of 121 studies on the registry; 19 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • In general good health
  • University of Southampton members of staff
  • Over 18 years old and able to provide informed consent
  • No known problems relating to the PIP joint

Exclusion criteria

Exclusion Criteria:

  • Volunteers involved in other studies concerned with the function and anatomy of the PIP joint which would have adverse effects on this study and/or the study in which they are currently involved.
  • Those undergoing treatment related to the PIP joint
  • No metallic object should be present in the scanner and therefore those with any implanted metallic devices, or other devices which may cause or be caused adverse effects (e.g. metal plate, pacemaker)
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
10 participants (actual)

Study arms

  • Other
    Motion capture, MR scan, CT scan

    All volunteers will go through the same data collection process

    Other: Motion capture · Diagnostic Test: MR scan · Diagnostic Test: CT scan

Interventions

  • OtherMotion capture

    Capture kinematics of finger movements

  • Diagnostic testMR scan

    Capture MR images of hand and fingers in three postures

  • Diagnostic testCT scan

    Capture CT images of hand and fingers in three postures

06

What researchers measure

Primary outcomes

  1. Capturing hand kinematics using Vicon optical motion capture

    Capture hand kinematics of 10 healthy volunteers

    Time frame: 3 years

  2. Capturing images of the soft tissue in the hand using MR imaging

    Capture MR images of the hand for same 10 healthy volunteers as Outcome 1

    Time frame: 3 years

  3. Capturing images of the bony structures in the hand using CT scanning

    Capture CT images of the hand for same 10 healthy volunteers as Outcome 1

    Time frame: 3 years

07

Study locations

1 site
  • University Hospital Southampton
    Southampton, Hampshire SO17 1BJ, United Kingdom
08

References and documents

Publications

  • Adams J, Ryall C, Pandyan A, Metcalf C, Stokes M, Bradley S, Warwick DJ. Proximal interphalangeal joint replacement in patients with arthritis of the hand: a meta-analysis. J Bone Joint Surg Br. 2012 Oct;94(10):1305-12. doi: 10.1302/0301-620X.94B10.29035. PubMed 23015553 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 15, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03094962
Lead sponsor
University of Southampton
Responsible party
Sponsor
First posted
Mar 29, 2017
Start date
Jan 21, 2015
Primary completion
Sep 5, 2017
Completion
Sep 5, 2017
Last update
Nov 15, 2018

Study contacts

Christopher WG Phillips, PhD
principal investigator · University of Southampton

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Nov 2018. You cannot join it, but the record below documents what was studied.

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