An observational study in Intracranial Pressure, Neurosurgery and Information Management, sponsored by RenJi Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2017-09-15.
Sponsored by RenJi Hospital · Observational
The PANDA trial is a multicenter prospective observational study designed to analyze various ICP derived parameters and clinical status in neurosurgical critical patients through a new big data acquisition system.
Nowadays, intracranial pressure (ICP) monitoring is widely used as a way to evaluate intracranial status in neurosurgery department especially in neurosurgical critical patients. Most of us focus only on the mean ICP value while ignoring other ICP derived parameters, such ICP waveform, AMP, RAP, PRx, IAAC and so on. However, it is reported that these parameters can reflect the status of intracerebral circulation, cerebrospinal compensatory reserve and brain compliance and can often be indicative of impending neurological deterioration and even outcome of patients. The PANDA trial is a multicenter prospective observational study designed to investigate the relationship between these ICP derived parameters and clinical status and to uncover the mechanism behind it. We will use a brand-new automatic big data collecting and storing system to continuously acquire patients' physiological information such as blood pressure, ICP, ETCO2，EEG etc. before analysis. Hopefully, this trial will reveal what is happening in the cranial cavity through the natural history of different kinds of intracranial lesion.
RenJi Hospital is the lead sponsor of 535 studies on the registry; 244 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients with intracranial lesion
Exclusion Criteria:
Glasgow Outcome Scale(GOS)
Time frame: within 3 months after enrollment
Glasgow Coma Scale(GCS)
Time frame: within 3 months after enrollment
Disability Rating Scale (DRS)
Time frame: within 3 months after enrollment
Mean intracranial pressure(ICP) value
Time frame: throughout ICP monitoring, average 7 days
Correlation between pulse amplitude and mean intracranial pressure(RAP)
Time frame: throughout ICP monitoring, average 7 days
Pressure-reactivity index(PRx)
Time frame: throughout ICP monitoring, average 7 days
Pulse amplitude of ICP(AMP)
Time frame: throughout ICP monitoring, average 7 days
ICP-arterial blood pressure(ABP) wave amplitude correlation(IAAC)
Time frame: throughout ICP monitoring, average 7 days
Cerebral perfusion pressure(CPP)
Time frame: throughout ICP monitoring, average 7 days
This study is status unknown, as verified in Mar 2017. You cannot join it, but the record below documents what was studied.
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RenJi Hospital