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CompletedNCT03072784Updated Mar 9, 2017

Aortic Cross Clamping Time, and Postoperative Respiratory Function

An interventional study of aortic cross clamping in Bypass Complication and Respiratory Complication, sponsored by Assiut University. Completed at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2017-03-09.

Sponsored by Assiut University · Not applicable, Interventional, and Other

From the registry’s dates

  • Registered 2 years after the study started (first participant enrolled Feb 2015, registered Feb 2017).
Phase
Not applicable
Study type
Interventional
Enrollment
53
Allocation
Non-randomized
Sex
All
01

Study summary

Does the duration of cardiopulmonary bypass, and aortic cross clamping affects the post operative pulmonary function.

Read the detailed description

Cardiac surgery usually is done under cardiopulmonary bypass. As the blood contacts with the artificial tubing of the circuit, there is release of mediators which affects pulmonary function. Of no doubt that the duration of cardiopulmonary bypass, and cross clamping time, will affect the spell over of such mediators. Follow up of the pulmonary function, and arterial blood gas is mandatory in such group of patients.

02

Conditions studied

  • Bypass Complication
  • Respiratory Complication
03

In context

Lead sponsor

Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.

Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • adult patients
  • elective open heart surgery

Exclusion criteria

Exclusion Criteria:

  • Patients with myocardial ischemia or previous infarction
  • low ejection fraction \<30%
  • history of AF
  • implanted pacemaker
  • uncontrolled hypertension
  • renal impairment (creatinine >1.8 mg/dl)
  • hepatic dysfunction
  • insulin dependent diabetes
  • chronic pulmonary disease
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
53 participants (actual)

Study arms

  • Active comparator
    group S

    short time \<90 m aortic cross clamping

    Procedure: aortic cross clamping

  • Active comparator
    group L

    \> 90 minutes aortic cross clamping

    Procedure: aortic cross clamping

Interventions

  • Procedureaortic cross clamping

    duration of cross clamping, less than 90 minutes, or more than 90 minutes

06

What researchers measure

Primary outcomes

  1. quality of oxygenation

    PaO2 mmHg

    Time frame: 48 hours postoperative

Secondary outcomes

  1. time to extubation

    time to extubate in minutes

    Time frame: 24 hours postoperative

  2. ventilation

    respiratory rate (breath/minute)

    Time frame: 48 hours postoperative

  3. carbon dioxide

    PaCO2 mmhg

    Time frame: 48 hours

07

Study locations

1 site
  • Emad Zarief Kamel Said
    Assiut, 71111, Egypt
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 9, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT03072784
Lead sponsor
Assiut University
Responsible party
Emad Zarief , MD (Lecturer of Anesthesia and critical care Medicine, Assiut University) — Principal investigator
First posted
Mar 7, 2017
Start date
Feb 1, 2015
Primary completion
Apr 20, 2016
Completion
Aug 25, 2016
Last update
Mar 9, 2017

Study contacts

Emad Z kamel Said, MD
principal investigator · Assiut University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2017. You cannot join it, but the record below documents what was studied.

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