An observational study in Gastric Bypass Surgery, Obesity and Bone Loss, sponsored by Hvidovre University Hospital. Status unknown at 1 site in Denmark. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2017-02-08.
Sponsored by Hvidovre University Hospital · Observational
Bone mineral density (BMD) is decreased after Roux-en-Y gastric bypass (RYGB) but whether RYGB induces changes in BMD beyond adaptation to major weight loss is not known. We aim to investigate BMD changes in weight bearing (hip, lumbal columna) and in non-weight bearing (forearm) regions before and after maximal weight loss at 1 year and after weight stabilisation at 4 years after RYGB. Moreover, plasma markers of bone turnover will be studied at fasting and during oral glucose tolerance test.
Hvidovre University Hospital is the lead sponsor of 295 studies on the registry; 21 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Participants will be recruited from a previously investigated cohort of 20 subjects undergoing Roux-en-Y gastric bypass surgery (NCT 01202526). The previous study aimed at investigating acute and long term changes in insulin sensitivity and secretion, whereas the present follow-up study investigates changes in bone metabolism as the primary outcome.
Exclusion Criteria:
Recruited from a previously investigated cohort (NCT 01202526)
Procedure: Roux-en-Y gastric bypass
Recruited from a previously investigated cohort (NCT 01202526)
Procedure: Roux-en-Y gastric bypass
Roux-en-Y gastric bypass surgery for morbid obesity
Changes in bone mineral density of non-weight bearing bone
DXA scans of forearm
Time frame: 1 year, 4 years
Changes in bone mineral density of weightbearing bone
DXA scans of hip and lumbal columna
Time frame: 1 year, 4 years
Plasma markers of bone turnover
At fasting
Time frame: 1 week, 3 months, 1 year, 4 years
Plasma markers of bone turnover
during OGTT
Time frame: 3 months, 1 year, 4 years
Plan to share: No
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This study is status unknown, as verified in Feb 2017. You cannot join it, but the record below documents what was studied.
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Hvidovre University Hospital