An interventional study of Exercise + Estrogen and Exercise + Placebo in Estrogen Supplementation, sponsored by University of Aarhus. Completed at 1 site in Denmark. Open to female participants aged 40 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-09-27.
Sponsored by University of Aarhus · Not applicable, Interventional, and Prevention
Purpose: to study the effect of estrogen replacement on muscle hypertrophy in response to 12 weeks resistance training in postmenopausal women Hypothesis: Transdermal administration of 17-β estradiol enhance the anabolic effect of resistance training on muscle mass, strength in postmenopausal women Primary outcome: Muscle hypertrophy (muscle CSA, muscle fiber type specific CSA) Secondary outcome: Messenger RiboNucleic Acid (mRNA)(real-time PCR), protein (western blotting), satellite cell proliferation and activation, Strength, functional test, muscle protein synthese.
Design: Two groups of healthy postmenopausal women (½-5 years after menopause) who have not performed regular resistance exercise (\<1 times per week) the last two years. Randomized, controlled intervention study +/- transdermal administration of estrogen (17-β estradiol). Both groups perform 12 weeks of supervised progressive resistance training (3/week) aiming to induce muscle hypertrophy in the legs.
University of Aarhus is the lead sponsor of 1,274 studies on the registry; 183 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Strength training 3 times a week for 12 weeks. Estrogen patches which provide 100 um pr. 24 hours.
Other: Exercise + Estrogen
Strength training 3 times a week for 12 weeks. Placebo patches.
Other: Exercise + Placebo
12 weeks resistance training and estrogen patches
12 weeks resistance training and placebo patches
Muscle hypertrophy
muscle cross sectional area measured by Magnetic resonance imaging (MR) -scans
Time frame: 12 weeks
Muscle fiber hypertrophy
Histology analysis of muscle fiber area
Time frame: 12 weeks
Muscle strength
Maximal isometric muscle strength
Time frame: 12 weeks
tendon size
Tendon cross sectional area measured by MR-scan
Time frame: 12 weeks
Fat cell size
Analysis of fat cell size (diameter)
Time frame: 12 weeks
Fat mass
Dual-energy X-ray absorptiometry (DXA) scan of total fat mass
Time frame: 12 weeks
Fat free mass
Fat free mass measured by DXA scan
Time frame: 12 weeks
This study is completed, as verified in Jun 2018. You cannot join it, but the record below documents what was studied.
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University of Aarhus