An interventional study of fluid challenge in Coronary Artery Bypass Graft, sponsored by University Medical Center Groningen. Completed at 1 site in Netherlands. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2018-05-18.
Sponsored by University Medical Center Groningen · Not applicable, Interventional, and Diagnostic
In this study, the investigators propose to investigate a novel technique for fluid responsiveness prediction. It is based on the occurrence of an extra systole, which induces a preload variation: Extra systoles are comprised by, first, the premature/ectopic beat with decreased cardiac preload, then, the post-ectopic beat with moderately increased preload.
Consequently, the post ectopic beat is associated with a Frank-Starling curve right shift but is otherwise a normal sinus beat. As such, the post-ectopic beat elucidates and predicts the hemodynamic effect of increasing preload, i.e. giving fluids
79 studies on the registry are indexed under Cardiac Complexes, Premature; 13 are open to participants now.
This study's enrollment of 60 is below the median of 86 across 40 interventional studies indexed under Cardiac Complexes, Premature.
Browse Cardiac Complexes, Premature studies →University Medical Center Groningen is the lead sponsor of 609 studies on the registry; 174 are open to participants now.
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Exclusion Criteria:
Other: fluid challenge
At two pre-defined time points during the procedure, enrolled patients will receive a fluid bolus of 5 ml/kg during 5 minutes
fluid challenge response in stroke volume
To investigate if post-ectopic induced changes in blood pressure before a fluid bolus (5 ml/kg) predicts the fluid induced change in cardiac stroke volume
Time frame: during operation
Plan to share: No
This study is completed, as verified in May 2018. You cannot join it, but the record below documents what was studied.
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University Medical Center Groningen