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CompletedNCT02997475SRBNUpdated Jan 17, 2023

Neural Bases of Multiple Forms of Self-regulatory Control in Bulimia Nervosa

An observational study in Bulimia Nervosa, sponsored by University of California, San Diego. Completed at 1 site in United States. Open to female participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-01-17.

Sponsored by University of California, San Diego · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
89
Ages
18 Years to 35 Years
Sex
Female
01

Study summary

The purpose of this study is to investigate areas of the brain responsible for self-regulation in adult women who have never had an eating disorder with women who have bulimia nervosa. More specifically, investigators are interested in changes in brain activation (e.g., changes in blood flow and oxygen use) when inhibiting responses and regulating emotions. Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

02

Conditions studied

  • Bulimia Nervosa

Keywords

  • Bulimia Nervosa
  • Bulimia
  • fMRI
  • Emotion Regulation
  • Response Inhibition
03

In context

Bulimia

319 studies on the registry are indexed under Bulimia; 53 are open to participants now.

This study's enrollment of 89 is above the median of 76 across 58 observational studies indexed under Bulimia.

Browse Bulimia studies →

Lead sponsor

University of California, San Diego is the lead sponsor of 958 studies on the registry; 191 are open to participants now.

Of its 110 completed or terminated interventional studies of FDA-regulated products, 70 (64%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Women (ages 18-35 years) with bulimia nervosa, and age- and BMI-matched healthy controls.

Eligibility criteria

General Inclusion Criteria:

  • Female
  • Right-handed
  • Between the ages of 18 and 35 years

    *For Women with Bulimia Nervosa:

  • Binge eating (i.e., eating a large amount of food while experiencing a sense of loss of control)
  • Purging via self-induced vomiting (other methods may also be endorsed)

General Exclusion Criteria:

  • Current significant medical illness or condition (e.g., diabetes, thyroid disease)
  • Pregnancy, planned pregnancy, or lactation during the study period
  • Non-removable metallic objects in the body
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
89 participants (actual)
Patient registry
No

Groups and cohorts

  • Women with Bulimia Nervosa
  • Women Healthy Controls
06

What researchers measure

Primary outcomes

  1. Self-Regulatory Control

    Functional Magnetic Resonance Imaging will be used to assess brain activation associated with motor inhibitory control and affect regulation in women with bulimia nervosa (BN)

    Time frame: Day 2 (fMRI Scan)

Secondary outcomes

  1. Goal-Directed Action Control

    An computerized instrumental learning task will be used to assess performance of women with and without bulimia nervosa.

    Time frame: Day 1

  2. Eating Disorder Relevance

    The Eating Disorder Examination (EDE) will be conducted to assess relative associations of motor, affective, and goal-directed action control with bulimia nervosa severity.

    Time frame: Day 0

07

Study locations

1 site
  • UCSD Eating Disorders Center for Treatment and Research
    San Diego, California 92121, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 17, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT02997475
Lead sponsor
University of California, San Diego
Collaborators
National Institute of Mental Health (NIMH), The Hilda & Preston Davis Foundation
Responsible party
Walter Kaye (Principal Investigator, University of California, San Diego) — Principal investigator
First posted
Dec 20, 2016
Start date
Jun 2016
Primary completion
Jul 31, 2022
Completion
Jul 31, 2022
Last update
Jan 17, 2023

Study contacts

Laura A. Berner, Ph.D.
study director · University of California, San Diego
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2023. You cannot join it, but the record below documents what was studied.

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