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Status unknownNCT02981589Updated Jul 2, 2021

Weaning Outcome From Invasive Mechanical Ventilation

An observational study in Patients Requiring Endotracheal Intubation and Invasive Mechanical Ventilation, sponsored by Beijing Chao Yang Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-07-02.

Sponsored by Beijing Chao Yang Hospital · Observational

The sponsor has not verified this record recently (last verified Jun 2021), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
300
Ages
18 Years and older
Sex
All
01

Study summary

The main purpose of the present study was to explore the weaning failure rate from invasive mechanical ventilation and to identify risk factors of weaning failure.

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Conditions studied

  • Patients Requiring Endotracheal Intubation and Invasive Mechanical Ventilation
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In context

Lead sponsor

Beijing Chao Yang Hospital is the lead sponsor of 135 studies on the registry; 49 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients requiring endotracheal intubation and invasive mechanical ventilation

Inclusion criteria

  • Requiring endotracheal intubation and invasive mechanical ventilation

Exclusion criteria

Exclusion Criteria:

  • Duration of invasive mechanical ventilation \< 48 hours；
  • Presence of tracheostomy；
  • Presence of upper airway obstruction.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
300 participants (estimated)
Patient registry
No

Interventions

  • DeviceInvasive mechanical ventilation

    Invasive ventilation was performed to all eligible patients. When patients met predefined criteria, spontaneous breathing trial was performed. Given spontaneous breathing trial passed, patients were extubated; on the contrary, patients would continue to receive invasive ventilation. If patients had respiratory failure after extubation, reintubation and invasive ventilation were necessary.

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What researchers measure

Primary outcomes

  1. Weaning failure rate

    Time frame: 3.5 years

  2. Spontaneous breathing trial failure rate

    Time frame: 3.5 years

  3. Extubation failure rate

    Time frame: 3.5 years

Secondary outcomes

  1. ICU mortality

    Time frame: 3.5 years

  2. Hospital mortality

    Time frame: 3.5 years

  3. ICU length of stay

    Time frame: 3.5 years

  4. Hospital length of stay

    Time frame: 3.5 years

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Study locations

1 of 1 sites recruiting
  • Respiratory intensive care unit, Beijing Chao Yang Hospital Jingxi Campus
    Beiling, China
    Recruiting
08

References and documents

Publications

  • Luo Z, Zheng Y, Yang L, Liu S, Zhu J, Zhao N, Pang B, Cao Z, Ma Y. Neutrophil/lymphocyte ratio is helpful for predicting weaning failure: a prospective, observational cohort study. J Thorac Dis. 2018 Sep;10(9):5232-5245. doi: 10.21037/jtd.2018.08.68. PubMed 30416770 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 2, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02981589
Lead sponsor
Beijing Chao Yang Hospital
Responsible party
Zujin Luo (MD, Beijing Chao Yang Hospital) — Principal investigator
First posted
Dec 5, 2016
Start date
Jul 2013
Primary completion
Dec 2023 (estimated)
Completion
Mar 31, 2024 (estimated)
Last update
Jul 2, 2021

Study contacts

Zujin Luo, MD
Contact
xmjg2002@163.com
Zujin Luo, MD
principal investigator · Beijing Chao Yang Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.

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