An interventional study of Artificial shrinkage in Vitrification, sponsored by Dar AlMaraa Center. Status unknown at 1 site in Egypt. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2016-11-29.
Sponsored by Dar AlMaraa Center · Not applicable, Interventional, and Treatment
Investigators aim to investigate the effect of elimination of blastocoelic fluid by creating a large hole in the zona pellucida at the cellular junction of the trophectoderm cells located far away from the inner cell mass with a laser pulse before vitrification.
Human blastocyst formation begins about 5 days after injecting a single sperm into an oocyte in ICSI cycle or incubation of them in IVF cycle. Human blastocyst consists of cells forming an outer layer called trophotoderm that will form the placenta in case of successful implantation, an inner cell mass which become the fetus, a fluid-filled blastocoel cavity in the center, and a surrounding zone pellucida from which the embryo hatches to implant in the uterus. Human blastocyst contains a large amount of liquid in the blastocoel, which alters the infiltration of vitrification solution during the vitrification procedures leading to ice crystal formation. Therefore, investigators need to compare blastocyst survival, clinical pregnancy and implantation rates between vitrified untreated expanded blastocysts and vitrified blastocysts with artificially eliminated blastocoels by a laser pulse prior to vitrification
Dar AlMaraa Center is the lead sponsor of 2 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Elimination of blastocoelic fluid by creating a large hole in the zona pellucida at the cellular junction of the trophectoderm cells located far away from the inner cell mass with a laser pulse before vitrification.
Procedure: Artificial shrinkage
Vitrify expanded blastocysts.
Artificially eliminated blastocoelic fluid before vitrification procedures.
Implantation rate
number of intrauterine gestational sacs over the total number of embryos transferred
Time frame: 1 month
This study is status unknown, as verified in Nov 2016. You cannot join it, but the record below documents what was studied.
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Dar AlMaraa Center