An interventional study of Red blood cells in Organ Preservation, sponsored by Post Graduate Institute of Medical Education and Research, Chandigarh. Status unknown at 1 site in India. Open to participants aged 16 Years to 70 Years. Per ClinicalTrials.gov, last updated 2016-11-02.
Sponsored by Post Graduate Institute of Medical Education and Research, Chandigarh · Not applicable, Interventional, and Treatment
The lungs retrieved from the brain dead multi organ donor will be placed in a lab . They will be connected to a ventilator and preservative solution will be circulated through it . Blood will be added to the fluid depending on the group to which the lungs are allocated and its effects on lung function will be seen
The lungs of a brain dead multi organ donor will be retrieved according to standard protocol. Once a decision is made not to transplant the lungs either because of not satisfying ideal criteria or in the absence of a potential recipient they will be included in the study.They will be ventilated optimally and connected to a cardiopulmonary bypass machine for circulating preservative solution through it . Red blood cells will be added to the solution either initially or later depending on the group to which it is allocated .Monitoring of mechanical and gas exchange function and pathological examination of the lungs will be performed at various time points to observe the effect of red blood cells. The lungs will be properly discarded at the end of the procedure and will not be used for transplantation.
Post Graduate Institute of Medical Education and Research, Chandigarh is the lead sponsor of 290 studies on the registry; 42 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Lung preservative solution without red blood cells will be used for perfusion in the initial 2 hours followed by addition of red blood cells for the next two hours
Other: Red blood cells
Lung preservative solution will contain red blood cells for the first two hours followed by acellular perfusate for the next two hours
Other: Red blood cells
Packed red blood cells to final hematocrit of 14%
Compliance
Measured from the airway pressure on ventilator
Time frame: From beginning of perfusion to 4 hours after that
Partial pressure to Inspired oxygen concentration ratio
Ratio of partial pressure of oxygen in perfusate to fraction of inspired oxygen
Time frame: From beginning of perfusion to 4 hours after that
Pulmonary vascular resistance
Calculated from measured pulmonary artery pressure and pump flow
Time frame: From beginning of perfusion to 4 hours after that
Lung injury score
By pathological examination
Time frame: From beginning of perfusion to 4 hours after that
Plan to share: No
This study is status unknown, as verified in Oct 2016. You cannot join it, but the record below documents what was studied.
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Post Graduate Institute of Medical Education and Research, Chandigarh