An interventional study of Handheld dynamometry (handgrip strength) in Ventilator Weaning, Hand Strength and Respiration, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-07-02.
Sponsored by Assistance Publique - Hôpitaux de Paris · Not applicable, Interventional, and Supportive care
The purpose of this study is to test the association between ICU acquired weakness as evaluated by dominant handheld dynamometry (handgrip) and the mechanical ventilation weaning outcome
Previous studies have evidenced that Intensive Care Unit acquired peripheral muscle weakness may lead to delayed mechanical ventilation weaning (i.e difficult or prolonged weaning according to guidelines). Nevertheless, no study has ever tested the association between handgrip strength and extubation outcome. The investigators have generated the hypothesis that ICU acquired weakness, as tested by handgrip strength might be associated with extubation outcome. The investigators have planned to include 240 patients. Handgrip strength will be monitored, along with a full muscular assessment through Medical Research Council score by the attending physiotherapist. Physicians in charge of the patients will be blinded to these values and the weaning protocol will continue according to guidelines.
Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,505 studies on the registry; 1,006 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
All included patients will have a blinded evaluation of handgrip strength before weaning process.
Procedure: Handheld dynamometry (handgrip strength)
Patients will perform handgrip strength dynamometry through holding the device in their dominant hand with the maximum strength, with standardized arm and body positions, as well as incentives
extubation outcome according to handgrip strength value
Each mechanical ventilation weaning trial
Time frame: 7 days
Association between handgrip strength and difficulty of weaning according to guidelines
Each mechanical ventilation weaning trial
Time frame: 7 days
Association between handgrip strength and cough strength as assessed through peak expiratory flow evaluated with a portable spirometer
Each mechanical ventilation weaning trial
Time frame: 7 days
Association between handgrip strength and maximal inspiratory strength during a brief inspiratory valve occlusion on the ventilator
Each mechanical ventilation weaning trial
Time frame: 7 days
Association between handgrip strength and peripheral muscular strength evaluated by the Medical Research Council score
Each mechanical ventilation weaning trial
Time frame: 7 days
Association between handgrip strength and the peripheral muscular strength evaluated by the Medical Research Council score. (Global score and its components)
Each mechanical ventilation weaning trial
Time frame: 7 days
Association between handgrip strength defined Intensive Care Unit acquired weakness and Intensive Care Unit and hospital length of stay
Time frame: 18 months
Association between handgrip strength defined Intensive Care Unit acquired weakness and Intensive Care Unit and hospital survival
Time frame: 18 months
Plan to share: No
This study is completed, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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Assistance Publique - Hôpitaux de Paris