An observational study in Appetitive Behavior and Obesity, sponsored by University of Southern California. Completed at 1 site in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-04-20.
Sponsored by University of Southern California · Observational
This study is aimed at understanding neuroendocrine responses to different types of sugars and how this influences feeding behavior among lean, overweight, and obese individuals.
The investigators have previously combined functional magnetic resonance imaging (fMRI) with hormonal and behavioral assessments to better understand the impacts of glucose and fructose on appetite and its central regulation in humans and have made important observations in lean individuals linking fructose consumption to overeating and obesity. The investigators now propose to expand this work by examining the impacts of glucose and fructose ingested together (sucrose), as occurs in real life, and by examining effects of a common non-nutritive sweetener, sucralose, on brain and appetitive response. The investigators propose a random-order crossover design to determine the effects of caloric and non-nutritive sweeteners among lean, overweight, and obese participants. The investigators will measure circulating levels of hormones involved in satiety signaling, quantify food intake, and measure brain activity using blood-oxygen level dependent and arterial spin labeling methods and functional connectivity analyses.
6,570 studies on the registry are indexed under Obesity; 1,718 are open to participants now.
This study's enrollment of 114 is below the median of 132 across 1,338 observational studies indexed under Obesity.
Browse Obesity studies →University of Southern California is the lead sponsor of 789 studies on the registry; 136 are open to participants now.
Of its 69 completed or terminated interventional studies of FDA-regulated products, 32 (46%) have results posted.
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Participants in the greater Los Angeles area will be recruited. Lean, overweight, and obese participants will be recruited.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Individuals ages 18 to 35 years of age with body mass index (BMI) 30-40 kg/m2
Individuals ages 18 to 35 years of age with BMI of 19-24.9 kg/m2
Individuals ages 18 to 35 years of age with BMI of 25-29.9 kg/m2
Changes of Blood oxygen level-dependent (BOLD) signal responses to food vs non-food cues after ingestion of different types of sugar. BOLD signal responses to food cues will be compared at the level of whole brain and within a priori regions of interest.
These will be compared between ingestion of drinks and at level of whole brain and in regions of interest
Time frame: Sessions 1, 2, 3, 4
Cerebral Blood Flow Response
Arterial spin labeling with be used to determine brain areas with relative increases or decreases in CBF after ingestion of sucrose, glucose, or sucralose.
Time frame: Sessions 1, 2, 3, 4
Systemic Metabolite and Hormone Responses
The effects of sugar ingestion on changes in systemic metabolite (glucose) and hormone (insulin, GLP-1, leptin, ghrelin, peptide YY) levels will be assessed.
Time frame: Sessions 1, 2, 3, 4
Functional Connectivity between regions involved in regulation of food intake
Investigators will perform a physiological-psychological-interaction (PPI) analysis using the nucleus accumbens as the seed to explore brain regions showing increased functional connectivity to the seed during the food-cue task.
Time frame: Sessions 1, 2, 3, 4
Appetite Ratings
Ratings of hunger and desire for food in response to food vs non-food cues will be analyzed using a repeated-measures ANOVA with condition (glucose, sucrose, sucralose) and stimulus (food vs non-food) as within-subject factors.
Time frame: Sessions 1, 2, 3, 4
Ad Libitum Food Intake
Total calories consumed and percent calories from sugar, fat and protein will be compared between conditions.
Time frame: Sessions 1, 2, 3, 4
The record gives a start of Feb 2016, a primary completion of Mar 2020 and a completion of Mar 2020. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Apr 2021. You cannot join it, but the record below documents what was studied.
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