An interventional study of Rubber dam isolation and aPDT in Root Canal Disinfection, sponsored by Fujian Medical University. Status unknown at 1 site in China. Open to participants aged 12 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-11-17.
Sponsored by Fujian Medical University · Not applicable, Interventional, and Treatment
The aim of this study is to compare the clinical effect of traditional root canal disinfection and aPDT on root canal disinfection. And provide the reference for clinical application and experience.
The study of groups:
Group1: Calcium hydroxide-based antibacterial dressing - two session root canal treatment Group2: aPDT - one session root canal treatment Microbiological measurement. Filled with sterile PBS, the root canals were sampled immediately before and after the disinfection procedures.
Fujian Medical University is the lead sponsor of 144 studies on the registry; 49 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Good general health, without syndromes or chronic systemic diseases; tooth with single root canal; a diagnosis of chronic periapical periodontitis; the lesions of the root tip was less than 6mm; recently (3months)did not take antibiotics.
Exclusion Criteria:
Refused to sign the informed consent document; systemic condition; uncooperative behavior; periodontal-endodontic lesions; allergic to photosensitizer; root apical absorption or destroy; A root canal anatomy of risk factors for the difficulty score ≧ 2
Rubber dam isolation, tooth disinfection，acess to the pulp of the chamber, microbiological sample with two sterile paper points, then mechanical preparation with NITIMTWO to 25#06, and cleaned with 5 ml of 2.5% NaClO between each endodontic file. At the end of the procedure, root canals were ultrasonic irrigated with 2.5% NaClO, 17% EDTA for 1 min followed by irrigation with 0.9% normal saline to remove the smear layer, then take the sample again, drying the canal and fill the canal with a commercial calcium hydroxide-based paste. After 2 weeks, the canals were filled with AH-Plus sealer and Gutta-percha by vertical condensation. The teeth were take crown restoration. Follow up at 3, 6, 12 and 24 months.
Procedure: Rubber dam isolation · Drug: 1% iodine tincture · Drug: 2.5%NaClO · Procedure: root canal preparation · Procedure: root canal obturation
Rubber dam isolation，tooth disinfection，acess to the pulp of the chamber, microbiological sample with two sterile paper points, then mechanical preparation with NITIMTWO to 25#06, and cleaned with 5 ml of 2.5% NaClO between each endodontic file. At the end of the procedure, root canals were ultrasonic irrigated with 2.5% NaClO for 1 min, then 17%EDTA for 1 min followed by irrigation with 0.9% normal saline to remove the smear layer, drying the canal, aPDT, then take the sample again. then dried the canals and filled the canals with AH-Plus sealer and Gutta-percha by vertical condensation. The teeth were take crown restoration. Follow up at 3, 6, 12 and 24 months.
Procedure: Rubber dam isolation · Device: aPDT · Drug: 1% iodine tincture · Drug: 2.5%NaClO · Procedure: root canal preparation · Procedure: root canal obturation
tooth was isolated using a rubber dam in order to avoid the outside microbe
Inject the photosensitizer (PS)to the parallel orifice of the canal,use the small file to stir the PS for 60 s,then irradiation 120 s.
Also known as: PADPLUS
use 1% iodine tincture to disinfect the crown of the teeth.in order to avoid the outside microbe
use 2.5% NaClO as irrigants
Also known as: sodium hypochlorite
mechanical preparation with NITIMTWO to 25#06, and cleaned with 5 ml of 2.5% NaClO between each endodontic file. At the end of the procedure, root canals were ultrasonic irrigated with 2.5% NaClO, 17% EDTA for 1 min followed by irrigation with 0.9% normal saline to remove the smear layer
filled the canals with AH-Plus sealer and Gutta-percha by vertical condensation
Quantification of bacteria by colony counting
Quantification the total bacteria
Time frame: 2 days after the sample taken
tooth pain
patient subjected sensation and doctor remark the symptoms after clinical examination
Time frame: 1 week and 3, 6, 12, 24 months after treatment
change of the lesion
take X ray, measure the lesion and compare to post-treatment
Time frame: 3, 6, 12, 24 months after treatment
Plan to share: No
No publications or documents are linked to this record.
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Fujian Medical University