An interventional study of GABA oral solution and Intramuscular GABA in Pain, sponsored by Aalborg University. Status unknown at 1 site in Denmark. Open to participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-01-10.
Sponsored by Aalborg University · Not applicable, Interventional, and Basic science
The effect of peripheral GABAA receptor activation on pain and sensitivity in healthy human subjects has never been investigated. However, as earlier studies suggest that activation of peripheral GABAA receptors is anti-nociceptive in rats, it is important to determine if these findings can be translated into human subjects to determine if peripheral GABAA receptors are a viable target for future analgesic drug development.
Subproject I This study will test if oral administration of GABA containing solutions will reduce the pain and sensitivity induced by application of capsaicin to the tongue of healthy human subjects. Thirty, pain-free men (n=15) and women (n=15) for the oral cavity study.
Subproject II This study will test the hypothesis that intramuscular injection of GABA alone will not be painful, but will reduce muscle pain sensitivity in healthy human subjects. Thirty, pain-free men (n=15) and women (n=15) will be recruited for the intramuscular GABA injection studies
Subproject III This study will test the hypothesis that intramuscular injection of GABA with glutamate will decrease the intensity of glutamate-evoked muscle pain in healthy human subjects. Thirty, pain-free men (n=15) and women (n=15) will be recruited for the intramuscular glutamate and GABA injection studies.
Aalborg University is the lead sponsor of 178 studies on the registry; 37 are open to participants now.
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This study will test if oral administration of GABA containing solutions will reduce the pain and sensitivity induced by application of capsaicin to the tongue of healthy human subjects.
Drug: GABA oral solution
This study will test the hypothesis that intramuscular injection of GABA alone will not be painful, but will reduce muscle pain sensitivity in healthy human subjects.
Drug: Intramuscular GABA
This study will test the hypothesis that intramuscular injection of GABA with glutamate will decrease the intensity of glutamate-evoked muscle pain in healthy human subjects.
Drug: Pain modulation
Oral mouth wash containing either GABA, lidocaine or distilled water will be used to decrease burning tongue pain produced by capsaicin
Also known as: gamma aminobutyric acid, lidocaine, distilled water, capsaicin
The effect of intramuscular injection of GABA or lorazepam will be compared with buffered isotonic saline
Also known as: gamma aminobutyric acid, lorazepam, buffered isotonic saline
The effect of GABA alone or in combination with lorazepam on muscle pain produced by intramuscular injection of glutamate will be assessed.
Also known as: gamma butyric acid, glutamate, lorazepam
Pain Intensity Rating
visual analogue scale
Time frame: continuously for 95 minutes
Jaw Function Tests
maximal jaw opening, maximal bite force
Time frame: every 5 min for 50 minutes
Quantitative Sensory testing
Pressure detection and pain threshold, thermal detection and pain threshold
Time frame: every 10 min for 90 min
Plan to share: No
This study is status unknown, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
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Aalborg University