An interventional study of repetitive transcranial magnetic stimulation in Transcranial Magnetic Stimulation, sponsored by Taipei Veterans General Hospital, Taiwan. Completed. Open to participants aged 40 Years to 80 Years. Per ClinicalTrials.gov, last updated 2017-06-20.
Sponsored by Taipei Veterans General Hospital, Taiwan · Not applicable, Interventional, and Treatment
The patients with chronic dysphagia secondary to first-ever stroke were randomly assigned to 2 groups: Group A: sham stimulation for 10 minutes , Group B: real rTMS for 10 minutes. rTMS conditioning: daily rTMS 10 min for 10 days. Assessments: 1. videofluoroscopy，2.Functional outcome swallowing scale (3 scales). 3. MEP measurements
While the reflex component of swallowing depends on swallowing centres in the brainstem, initiation of swallowing is a voluntary action that involves the integrity of motor areas of the cerebral cortex. Oropharyngeal dysphagia occurs in more than 50% of stroke patients. Aspiration pneumonia occurs in up to 20% of acute stroke patients and is a major cause of mortality after discharge. Oropharyngeal dysphagia is both underestimated and underdiagnosed as a cause of major nutritional and respiratory complications in stroke patients. Recently, transcranial magnetic stimulation (TMS) has been used to study the cortical input to swallowing control and has revealed that the topographic representation of esophageal motor function in the human cerebral cortex is bilateral but with consistent interhemispheric asymmetry unrelated to handedness.
In a number of recent studies, poststroke motor and dysphagia performance has been improved after daily treatment sessions with repetitive TMS (rTMS) using an excitatory frequency in patients with hemispheric ischaemic stroke due to occlusion of territories of the middle cerebral artery. Our hypothesis was that rTMS would facilitate dysphagia recovery.
7,287 studies on the registry are indexed under Stroke; 2,006 are open to participants now.
This study's enrollment of 5 is below the median of 50 across 5,370 interventional studies indexed under Stroke.
Browse Stroke studies →Taipei Veterans General Hospital, Taiwan is the lead sponsor of 325 studies on the registry; 72 are open to participants now.
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Exclusion Criteria:
Real repetitive transcranial magnetic stimulation + swallowing training
Device: repetitive transcranial magnetic stimulation
Sham repetitive transcranial magnetic stimulation + swallowing training
Device: repetitive transcranial magnetic stimulation
rTMS
functional outcome
points of Australian Therapy Outcome Measures-the Swallowing scale as assessed by a clinical therapist
Time frame: prior to treatment (baseline), on the next day after the 2 weeks treatment completion
videofluoroscopy
points of Penetration-Aspiration Scale as assessed by videofluoroscopy
Time frame: prior to treatment (baseline), on the next day after the 2 weeks treatment completion
cricopharyngeal motor evoked potentials
amplitude and latency measured by cricopharyngeal motor evoked potentials
Time frame: prior to treatment (baseline), on the next day after the 2 weeks treatment completion
No study locations are listed for this record.
Plan to share: No
This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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Taipei Veterans General Hospital, Taiwan