ClinicalTrials.gg
CompletedNCT02883725REGATEUpdated May 5, 2026

National Register of Oesophageal Atresia

An observational study in Esophageal Atresia, sponsored by University Hospital, Lille. Completed at 37 sites in 3 countries. Open to participants aged Up to 1 Year. Per ClinicalTrials.gov, last updated 2026-05-05.

Sponsored by University Hospital, Lille · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
1,460
Ages
Up to 1 Year
Sex
All
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Study summary

The esophageal atresia is a group of birth defects including a break in continuity of the esophagus with or without persistent communication with the trachea (tracheoesophageal fistula), sometimes associated (from 50%) of other malformations (heart, kidney, digestive ...).

The current prognosis for this ailment is good. However he persists a mortality (\<10%) and significant morbidity, firstly related malformations (heart, kidney, for example), and secondly with particularly difficult anatomical forms (Forms long defect) .

The prevalence of this condition is estimated to be 1/2500 in 3000 live births, making an estimated ± 2,500 new cases over to 10 years in France.

The current project aims to set up a national registry (Metropolitan France and Dom Tom) to measure the prevalence of esophageal atresia among live births, phenotypic characteristics, the circumstances of their diagnosis, and their initial future at short-term during the first year of life, at which time occurs the vast majority of deaths and complications in this disease.

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Conditions studied

  • Esophageal Atresia

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Keywords

  • Esophageal atresia
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In context

Esophageal Atresia

37 studies on the registry are indexed under Esophageal Atresia; 12 are open to participants now.

This study's enrollment of 1,460 is above the median of 50 across 19 observational studies indexed under Esophageal Atresia.

Browse Esophageal Atresia studies →

Lead sponsor

University Hospital, Lille is the lead sponsor of 631 studies on the registry; 142 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Up to 1 Year
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

All living newborns having a esophageal atresia supported in a neonatal unit, neonatal intensive care and pediatric surgery of France

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • To be born in France
  • To have a esophageal atresia

Exclusion criteria

Exclusion Criteria:

  • To be born abroad
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
1,460 participants (actual)
Patient registry
No

Groups and cohorts

  • Esophageal atresia

    Other: data collection

Interventions

  • Otherdata collection
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What researchers measure

Primary outcomes

  1. Number of esophageal atresia

    Time frame: 10 years

Secondary outcomes

  1. Data collection patient with esophageal atresia

    Circumstances of diagnosis, modalities of follow-up and clinical management

    Time frame: 10 years

  2. Total number of patients with complications

    Time frame: 10 years

  3. Death

    Time frame: 10 years

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Study locations

37 sites
  • CHU Félix-Guyon
    Saint-Denis, La Réunion, France
  • CHU Amiens-Picardie
    Amiens, France
  • CHU d'Angers
    Angers, France
  • CHRU Besançon
    Besançon, France
  • CHU de Bordeaux
    Bordeaux, France
  • CHRU Brest
    Brest, France
  • HFME de Lyon
    Bron, France
  • CHU de Caen
    Caen, France
  • CHU de Clermont-Ferrand
    Clermont-Ferrand, France
  • Hôpitaux Civils de Colmar
    Colmar, France
  • CHI Créteil
    Créteil, France
  • CHU Dijon Bourgogne
    Dijon, France
  • CHU de Grenoble
    La Tronche, France
  • AP-HP CHU Kremlin-Bicêtre
    Le Kremlin-Bicêtre, France
  • CH Le Mans
    Le Mans, France
  • CHRU,Hôpital Jeanne de Flandres
    Lille, France
  • CHU de Limoges
    Limoges, France
  • AP-HM La Timone
    Marseille, France
  • AP-HM Nord
    Marseille, France
  • CHRU de Montpellier
    Montpellier, France
  • CHU de Nantes
    Nantes, France
  • CHU de Nice
    Nice, France
  • CHR d'Orléans
    Orléans, France
  • AP-HP Armand Trousseau
    Paris, France
  • AP-HP Necker-Enfants malades
    Paris, France
  • AP-HP Robert-Debré
    Paris, France
  • CHU de Poitiers
    Poitiers, France
  • CHU de Reims
    Reims, France
  • CHU de Rennes
    Rennes, France
  • CHU de Rouen
    Rouen, France
  • CHU de Saint-Etienne
    Saint-Priest-en-Jarez, France
  • CHU de Strasbourg
    Strasbourg, France
  • CHU de Toulouse
    Toulouse, France
  • CHRU de Tours
    Tours, France
  • CHU de Nancy
    Vandœuvre-lès-Nancy, France
  • CHU de Pointe-à-Pitre
    Pointe-à-Pitre, Guadeloupe
  • CHU de Martinique
    Fort-de-France, 97200, Martinique
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References and documents

Publications

  • Lejeune S, Sfeir R, Rousseau V, Bonnard A, Gelas T, Aumar M, Panait N, Rabattu PY, Irtan S, Fouquet V, Le Mandat A, Cocci SN, Habonimana E, Lamireau T, Lemelle JL, Elbaz F, Talon I, Boudaoud N, Allal H, Buisson P, Petit T, Sapin E, Lardy H, Schmitt F, Levard G, Scalabre A, Michel JL, Jaby O, Pelatan C, De Vries P, Borderon C, Fourcade L, Breaud J, Arnould M, Tolg C, Chaussy Y, Geiss S, Laplace C, Drumez E, El Mourad S, Thumerelle C, Gottrand F. Esophageal Atresia and Respiratory Morbidity. Pediatrics. 2021 Sep;148(3):e2020049778. doi: 10.1542/peds.2020-049778. Epub 2021 Aug 19. PubMed 34413249 ↗

Related links

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 5, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02883725
Responsible party
Sponsor
First posted
Aug 30, 2016
Start date
Jan 1, 2008
Primary completion
Dec 31, 2016
Completion
Dec 31, 2019
Last update
May 5, 2026

Study contacts

Frédéric Gottrand, MD, PhD
principal investigator · University Hospital, Lille

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.

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