An observational study in Germinal Cancers of the Testicle, sponsored by Centre Hospitalier Universitaire Dijon. Status unknown at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2016-08-22.
Sponsored by Centre Hospitalier Universitaire Dijon · Observational
By analogy with the mouse, the activity of control pathways for transposable elements (TE) in foetal primordial germinal cells could prove to be a determinant for fertility in adulthood in humans. Moreover, defects in the control of transposable elements (TE) could also contribute to the aetiology of germinal testicular cancer, by inducing chromosomal instability and tumorigenesis. In this context, the aim is to analyse a specific type of adult germinal testicular cancers, seminomas. Directly related to our research interest, the histological, transcriptomic and epigenetic features of theses adult tumours are reminiscent of germinal cells normally present in foetuses. The investigator postulates that these similarities could also extend to the biology of transposable elements (TE), and in particular to the initiation of the control of these elements. The management of seminomas requires surgery, orchiectomy, which consists of the total excision of the affected testicles. Using high-resolution high-throughput sequencing techniques, we propose to analyse the control pathways of transposable elements (TE) in tumour samples harvested from surgical pieces in comparison with adjacent healthy tissue. The results obtained in these tumour samples will be compared with those in normal foetal gonad samples.
Centre Hospitalier Universitaire Dijon is the lead sponsor of 495 studies on the registry; 105 are open to participants now.
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men with germinal testicular cancer
Exclusion Criteria:
Genetic: Extraction of total RNA from healthy and tumour tissues
Genetic: Extraction of total RNA from healthy and tumour tissues
Genetic: Extraction of total RNA from healthy and tumour tissues
The role of Transposable Element in tumorigenesis seminomas adults
Transcriptomic analysis of adult seminomas
Time frame: through the study completion up to 36 months
This study is status unknown, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire Dijon