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RecruitingNCT02872987GMALLregistryUpdated Aug 5, 2026

GMALL Registry and Collection of Biomaterial: Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult Acute Lymphoblastic Leukemia (ALL) Patients and Related Diseases Associated With a Prospective Collection of Biomaterial

An observational study in Acute Lymphoblastic Leukemia, Leukemia and Non-Hodgkin's Lymphoma, sponsored by Goethe University. Recruiting at 147 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-05.

Sponsored by Goethe University · Observational

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Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
10,000
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-14

Among 16 studies in Precursor Cell Lymphoblastic Leukemia-Lymphoma by Goethe University — 2 open to participants now, 3 under way, none of them phase 3. Precursor Cell Lymphoblastic Leukemia-Lymphoma · Goethe University.

Started
2009
the only one that year
Observational
Only one
of the 16
Registered
12th of 16
by date

Among the 16 studies in Precursor Cell Lymphoblastic Leukemia-Lymphoma by Goethe University, this one is the only one that started in 2009, is the only observational one, and was the 12th registered.

Precursor Cell Lymphoblastic Leukemia-Lymphoma

2,584 studies on the registry are indexed under Precursor Cell Lymphoblastic Leukemia-Lymphoma; 473 are open to participants now.

Browse Precursor Cell Lymphoblastic Leukemia-Lymphoma studies →

Open to participants now

2 of the 16 studies in Precursor Cell Lymphoblastic Leukemia-Lymphoma by Goethe University are open now, in 2 countries. Recruiting first, the newest first:

By country, each count listing its studies:

All 2 open studies →

Where they have run

Who these studies take

Of the 370 Precursor Cell Lymphoblastic Leukemia-Lymphoma studies recruiting now, 96 (26%) set no upper age limit and 257 (69%) stop at 75 or younger; 247 take children under 18; 29 take healthy volunteers.

This study: 18 Years and older · all sexes · no healthy volunteers.

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Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 16 studies in Precursor Cell Lymphoblastic Leukemia-Lymphoma by Goethe University, or all of them as a file.
02

Study summary

The GMALL registry serves the purpose of ALL research and quality assurance. The Registry collects data about diagnostics, treatment and outcome of Adult ALL Patients in the clinical routine, whether or not the patient is treated within a clinical trial.

03

Conditions studied

  • Acute Lymphoblastic Leukemia
  • Leukemia
  • Non-Hodgkin's Lymphoma
04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Acute Lymphoblastic Leukemia or seleted NHL

Eligibility criteria

Inclusion Criteria:

  • Acute Lymphoblastic Leukemia (All Subtypes) if treated according to ALL protocols
  • Other Types of Leukemia (NK Cell Lymphoma/Leukemia, Biphenotypic Acute Leukemia) if treated according to ALL protocols
  • Non-Hodgkin's Lymphoma of Following Subtypes: Burkitt Lymphoma, B Cell Lymphoma, B- or T-lineage Lymphoblastic Lymphoma, Anaplastic Large Cell Lymphoma, Other NHL) if treated according to B-ALL protocols
  • Age minimum 18 yrs
05

Study design

Observational model
Other
Time perspective
Prospective
Enrollment
10,000 participants (estimated)
Target follow-up
15 Years
Patient registry
Yes

Groups and cohorts

  • B-ALL/NHL
  • ALL/ Lymphoblastic Lymphoma (LBL)
06

What researchers measure

Primary outcomes

  1. Overall survival

    Time frame: up to 10 years

Secondary outcomes

  1. Event free survival

    Time frame: up to 10 years

  2. Hematologic remission rate

    Time frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis

  3. Molecular remission rate

    Time frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis

  4. Positron Emission Tomography (PET) based remission evaluation

    Time frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis

  5. Remission duration

    Time frame: up to 10 years

  6. Relapse rate

    Time frame: up to 10 years

  7. Disease free survival

    Time frame: up to 10 years

  8. Early mortality

    Time frame: during induction therapy with a duration of approximately 6 - 8 weeks

  9. Mortality in Clinical Remission (CR)

    Time frame: up to 10 years

  10. Comorbidities

    Time frame: Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified

  11. Quality of life assessed by Quality of Life Questionnaire (QLQ-C30)

    Time frame: after treatment which is approximately 2.5 years from diagnosis

  12. Eastern Cooperative Oncology Group (ECOG) status

    Time frame: Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified

  13. Toxicities assessed by CTCAE v4.03

    Time frame: during treatment with an approximate duration of 2.5 years from diagnosis

07

Study locations

147 of 147 sites recruiting

Showing the first 100 of 147 sites across 2 countries. Choose a country and city above to see the rest.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Feb 2009, a primary completion of Dec 2030 and a completion of Dec 2035. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 4, 2016
First posted
Aug 19, 2016
Start
Feb 2009
Primary completionEst.
Dec 2030
CompletionEst.
Dec 2035
Last update
Aug 5, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 5, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02872987
Lead sponsor
Goethe University
Responsible party
Nicola Goekbuget (Head of GMALL, Goethe University) — Principal investigator
First posted
Aug 19, 2016
Start date
Feb 2009
Primary completion
Dec 2030 (estimated)
Completion
Dec 2035 (estimated)
Last update
Aug 5, 2026

Study contacts

Nicola Gökbuget, Dr. med.
Contact
goekbuget@em.uni-frankfurt.de
+496963016365
GMALL Study center
Contact
gmall@em.uni-frankfurt.de
Nicola Gökbuget, Dr. med.
principal investigator · University Hospital of Frankfurt (Main)

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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