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RecruitingNCT02872987GMALLregistryUpdated Aug 5, 2026

GMALL Registry and Collection of Biomaterial: Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult Acute Lymphoblastic Leukemia (ALL) Patients and Related Diseases Associated With a Prospective Collection of Biomaterial

An observational study in Acute Lymphoblastic Leukemia, Leukemia and Non-Hodgkin's Lymphoma, sponsored by Goethe University. Recruiting at 147 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-05.

Sponsored by Goethe University · Observational

Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
10,000
Ages
18 Years and older
Sex
All
01

Study summary

The GMALL registry serves the purpose of ALL research and quality assurance. The Registry collects data about diagnostics, treatment and outcome of Adult ALL Patients in the clinical routine, whether or not the patient is treated within a clinical trial.

02

Conditions studied

  • Acute Lymphoblastic Leukemia
  • Leukemia
  • Non-Hodgkin's Lymphoma
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Acute Lymphoblastic Leukemia or seleted NHL

Eligibility criteria

Inclusion Criteria:

  • Acute Lymphoblastic Leukemia (All Subtypes) if treated according to ALL protocols
  • Other Types of Leukemia (NK Cell Lymphoma/Leukemia, Biphenotypic Acute Leukemia) if treated according to ALL protocols
  • Non-Hodgkin's Lymphoma of Following Subtypes: Burkitt Lymphoma, B Cell Lymphoma, B- or T-lineage Lymphoblastic Lymphoma, Anaplastic Large Cell Lymphoma, Other NHL) if treated according to B-ALL protocols
  • Age minimum 18 yrs
04

Study design

Observational model
Other
Time perspective
Prospective
Enrollment
10,000 participants (estimated)
Target follow-up
15 Years
Patient registry
Yes

Groups and cohorts

  • B-ALL/NHL
  • ALL/ Lymphoblastic Lymphoma (LBL)
05

What researchers measure

Primary outcomes

  1. Overall survival

    Time frame: up to 10 years

Secondary outcomes

  1. Event free survival

    Time frame: up to 10 years

  2. Hematologic remission rate

    Time frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis

  3. Molecular remission rate

    Time frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis

  4. Positron Emission Tomography (PET) based remission evaluation

    Time frame: after induction and consolidation, approximately 6 - 8 weeks from diagnosis

  5. Remission duration

    Time frame: up to 10 years

  6. Relapse rate

    Time frame: up to 10 years

  7. Disease free survival

    Time frame: up to 10 years

  8. Early mortality

    Time frame: during induction therapy with a duration of approximately 6 - 8 weeks

  9. Mortality in Clinical Remission (CR)

    Time frame: up to 10 years

  10. Comorbidities

    Time frame: Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified

  11. Quality of life assessed by Quality of Life Questionnaire (QLQ-C30)

    Time frame: after treatment which is approximately 2.5 years from diagnosis

  12. Eastern Cooperative Oncology Group (ECOG) status

    Time frame: Time of diagnosis and up to 10 years during regular follow-up requests which are not pre-specified

  13. Toxicities assessed by CTCAE v4.03

    Time frame: during treatment with an approximate duration of 2.5 years from diagnosis

06

Study locations

147 of 147 sites recruiting
  • Universitätsklinikum Graz
    Graz, Austria
    Recruiting
  • LKH-Hochsteiermark Leoben
    Leoben, Austria
    Recruiting
  • Ordensklinikum Linz Elisabethinen
    Linz, Austria
    Recruiting
  • Universitätsklinikum St. Pölten
    Sankt Pölten, Austria
    Recruiting
  • Hanusch-Krankenhaus Wien
    Vienna, Austria
    Recruiting
  • University Hospital of Frankfurt (Main)
    Frankfurt am Main, Hesse 60590, Germany
    • GMALL Study Center · Contact · gmall@em.uni-frankfurt.de · +496963016366
    • Nicola Gökbuget, Dr. med. · Principal investigator
    Recruiting
  • Universitätsklinikum Aachen
    Aachen, Germany
    Recruiting
  • Klinikum Altenburger Land
    Altenburg, Germany
    Recruiting
  • Kreiskliniken Altötting
    Altötting, Germany
    Recruiting
  • Klinikum Aschaffenburg
    Aschaffenburg, Germany
    Recruiting
  • Klinikum Augsburg
    Augsburg, Germany
    Recruiting
  • Helios Klinikum Bad Saarow
    Bad Saarow, Germany
    Recruiting
  • Sozialstiftung Bamberg
    Bamberg, Germany
    Recruiting
  • Klinikum Bayreuth
    Bayreuth, Germany
    Recruiting
  • Charité Universitätsmedizin Berlin
    Berlin, Germany
    Recruiting
  • Evangelisches Waldkrankenhaus Spandau
    Berlin, Germany
    Recruiting
  • Helios Klinikum Berlin-Buch
    Berlin, Germany
    Recruiting
  • Vivantes Klinikum Neukölln
    Berlin, Germany
    Recruiting
  • Vivantes-Klinikum am Urban
    Berlin, Germany
    Recruiting
  • Evangelisches Krankenhaus Bielefeld
    Bielefeld, Germany
    Recruiting
  • Klinikum Bielefeld
    Bielefeld, Germany
    Recruiting
  • Augsuta Krankenanstalt Bochum
    Bochum, Germany
    Recruiting
  • Katholisches Klinikum Bochum
    Bochum, Germany
    Recruiting
  • Universitätsklinikum Knappschaftskrankenhaus Bochum
    Bochum, Germany
    Recruiting
  • Johanniter-Krankenhaus Bonn
    Bonn, Germany
    Recruiting
  • Universitätsklinikum Bonn
    Bonn, Germany
    Recruiting
  • Städtisches Klinikum Braunschweig
    Braunschweig, Germany
    Recruiting
  • Evangelische Diakonissenanstalt Bremen
    Bremen, Germany
    Recruiting
  • Klinikum Bremen-Mitte gGmbH
    Bremen, Germany
    Recruiting
  • Klinikum Chemnitz gGmbH
    Chemnitz, Germany
    Recruiting
  • Universitätsklinikum Köln
    Cologne, Germany
    Recruiting
  • Carl-Thiem-Klinikum Cottbus
    Cottbus, Germany
    Recruiting
  • Klinikum Darmstadt
    Darmstadt, Germany
    Recruiting
  • Städtisches Krankenhaus Dessau
    Dessau, Germany
    Recruiting
  • Klinikum Dortmund
    Dortmund, Germany
    Recruiting
  • St. Johannes-Hospital Dortmund
    Dortmund, Germany
    Recruiting
  • Klinikum Carl-Gustav-Carus
    Dresden, Germany
    Recruiting
  • Städtisches Klinikum Dresden
    Dresden, Germany
    Recruiting
  • Helios Klinikum Duisburg
    Duisburg, Germany
    Recruiting
  • Johanniter-Krankenhaus Duisburg
    Duisburg, Germany
    Recruiting
  • Krankenhaus Düren
    Düren, Germany
    Recruiting
  • Marien-Hospital Düsseldorf
    Düsseldorf, Germany
    Recruiting
  • Universitätsklinikum Düsseldorf
    Düsseldorf, Germany
    Recruiting
  • Helios Klinikum Erfurt
    Erfurt, Germany
    Recruiting
  • Universitätsklinikum Erlangen
    Erlangen, Germany
    Recruiting
  • St.-Antonius-Hospital Eschweiler
    Eschweiler, Germany
    Recruiting
  • Evang. Krankenhaus Essen-Werden
    Essen, Germany
    Recruiting
  • Universitätsklinikum Essen
    Essen, Germany
    Recruiting
  • Malteser Krankenhaus Flensburg
    Flensburg, Germany
    Recruiting
  • Klinikum Frankfurt-Oder
    Frankfurt, Germany
    Recruiting
  • Städt. Klinikum Frankfurt-Höchst
    Frankfurt, Germany
    Recruiting
  • Universitätsklinikum Freiburg
    Freiburg im Breisgau, Germany
    Recruiting
  • Klinikum Fulda
    Fulda, Germany
    Recruiting
  • Niels-Stensen-Kliniken Georgsmarienhütte
    Georgsmarienhütte, Germany
    Recruiting
  • Klinik der Justus-Liebig-Universität Gießen
    Giessen, Germany
    Recruiting
  • Wilhelm-Anton-Hospital Goch
    Goch, Germany
    Recruiting
  • Universitätsklinikum Göttingen
    Göttingen, Germany
    Recruiting
  • Universitätsklinikum Ernst-Moritz-Arndt-Universität
    Greifswald, Germany
    Recruiting
  • Städtisches Krankenhaus Gütersloh
    Gütersloh, Germany
    Recruiting
  • Katholisches Krankenhaus Hagen gGmbH
    Hagen, Germany
    Recruiting
  • Krankenhaus St. Elisabeth und St. Barbara Halle/Saale
    Halle, Germany
    Recruiting
  • Martin-Luther-Universität Halle-Wittenberg
    Halle, Germany
    Recruiting
  • Asklepios Klinik Altona Hamburg
    Hamburg, Germany
    Recruiting
  • Asklepios Klinik St. Georg Hamburg
    Hamburg, Germany
    Recruiting
  • Universitätsklinikum Hamburg-Eppendorf
    Hamburg, Germany
    Recruiting
  • Evangelisches Krankenhaus Hamm gGmbH
    Hamm, Germany
    Recruiting
  • St. Barbara-Klinik Hamm
    Hamm, Germany
    Recruiting
  • Klinikum Siloah Hannover
    Hanover, Germany
    Recruiting
  • Medizinische Hochschule Hannover
    Hanover, Germany
    Recruiting
  • Universitätsklinikum Heidelberg
    Heidelberg, Germany
    Recruiting
  • SLK Kliniken Heilbronn
    Heilbronn, Germany
    Recruiting
  • Marienhospital Herne
    Herne, Germany
    Recruiting
  • St. Bernward Krankenhaus Hildesheim
    Hildesheim, Germany
    Recruiting
  • Universitätsklinikum des Saarlandes
    Homburg/Saar, Germany
    Recruiting
  • Klinikum Idar-Oberstein
    Idar-Oberstein, Germany
    Recruiting
  • Universitätsklinikum Jena
    Jena, Germany
    Recruiting
  • St. Vincentius-Kliniken Karlsruhe
    Karlsruhe, Germany
    Recruiting
  • Städt. Klinikum Karlsruhe
    Karlsruhe, Germany
    Recruiting
  • Klinikum Kassel GmbH
    Kassel, Germany
    Recruiting
  • Städtisches Krankenhaus Kiel
    Kiel, Germany
    Recruiting
  • Universitätsklinikum Schleswig-Holstein
    Kiel, Germany
    Recruiting
  • Gemeinschaftsklinikum Mittelrhein Koblenz
    Koblenz, Germany
    Recruiting
  • Helios Klinikum Krefeld
    Krefeld, Germany
    Recruiting
  • Klinikum Kulmbach
    Kulmbach, Germany
    Recruiting
  • Klinikum Landshut
    Landshut, Germany
    Recruiting
  • Universitätsklinikum Leipzig
    Leipzig, Germany
    Recruiting
  • Klinikum Lippe-Lemgo
    Lippe, Germany
    Recruiting
  • Klinikum der Stadt Ludwigshafen
    Ludwigshafen, Germany
    Recruiting
  • Sana Kliniken Lübeck
    Lübeck, Germany
    Recruiting
  • Universitätsklinikum Schleswig-Holstein - Campus Lübeck
    Lübeck, Germany
    Recruiting
  • Märkische Kliniken Lüdenscheid
    Lüdenscheid, Germany
    Recruiting
  • Universitätsklinikum Magdeburg
    Magdeburg, Germany
    Recruiting
  • Universitätsklinikum Mainz
    Mainz, Germany
    Recruiting
  • Klinikum Mannheim
    Mannheim, Germany
    Recruiting
  • Universitätsklinikum Marburg
    Marburg, Germany
    Recruiting
  • Klinikum Hochsauerland Meschede
    Meschede, Germany
    Recruiting
  • Johannes Wesling Klinikum Minden
    Minden, Germany
    Recruiting
  • Kliniken Maria Hilf Mönchengladbach
    Mönchengladbach, Germany
    Recruiting
  • Stauferklinikum Mutlangen
    Mutlangen, Germany
    Recruiting
  • Klinikum München-Bogenhausen
    München, Germany
    Recruiting

Showing the first 100 of 147 sites across 2 countries.

07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT02872987
Lead sponsor
Goethe University
Responsible party
Nicola Goekbuget (Head of GMALL, Goethe University) — Principal investigator
First posted
Aug 19, 2016
Start date
Feb 2009
Primary completion
Dec 2030 (estimated)
Completion
Dec 2035 (estimated)
Last update
Aug 5, 2026

Study contacts

Nicola Gökbuget, Dr. med.
Contact
goekbuget@em.uni-frankfurt.de
+496963016365
GMALL Study center
Contact
gmall@em.uni-frankfurt.de
Nicola Gökbuget, Dr. med.
principal investigator · University Hospital of Frankfurt (Main)

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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