An observational study in Diabetes Mellitus, Type 2, sponsored by RCSI & UCD Malaysia Campus. Completed at 1 site in Malaysia. Open to participants aged 10 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-07-27.
Sponsored by RCSI & UCD Malaysia Campus · Observational
Early onset type 2 diabetes mellitus among adolescents/youth (YT2DM) is a rising phenomenon. The pathophysiology has been studied primarily on non-Asian populations while literature on incretin effect is scarce. The investigators evaluated insulin sensitivity, beta-cell function, incretin hormones and their effect in YT2DM from a multiethnic Malaysian population. The characterization of this population may enable us to better tailor their antidiabetic care.
9,359 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,318 are open to participants now.
This study's enrollment of 48 is below the median of 300 across 1,588 observational studies indexed under Diabetes Mellitus, Type 2.
Browse Diabetes Mellitus, Type 2 studies →RCSI & UCD Malaysia Campus is the lead sponsor of 4 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
30 youths with type 2 diabetes with 18 gender- and age-matched healthy controls
Exclusion Criteria:
(i) 2-hour 75g OGTT with sampling of glucose, insulin, C-peptide and GLP-1 hormone, with sampling at fasting (time zero) and 30, 60, 90, 120 min after the glucose load. (ii) 1-hour IVGTT, with sampling at time 10 and 1 min, after which glucose (300 mg/kg body weight) infused in a contralateral vein within 30 s, starting at time zero. Blood further sampled for glucose, insulin and C-Peptide with sampling schedule: 3, 5, 6, 8, 10, 15, 20, 25,30 ,40 ,50 ,60 min; (iii) computed tomography scan, (CT) for abdominal subcutaneous and visceral fat quantification.
Other: OGTT and IVGTT tests
(i) 2-hour 75g OGTT with sampling of glucose, insulin, C-peptide and GLP-1 hormone, with sampling at fasting (time zero) and 30, 60, 90, 120 min after the glucose load. (ii) 1-hour IVGTT, with sampling at time 10 and 1 min, after which glucose (300 mg/kg body weight) infused in a contralateral vein within 30 s, starting at time zero. Blood further sampled for glucose, insulin and C-Peptide with sampling schedule: 3, 5, 6, 8, 10, 15, 20, 25,30 ,40 ,50 ,60 min; (iii) computed tomography scan, (CT) for abdominal subcutaneous and visceral fat quantification.
Other: OGTT and IVGTT tests
Quantitative Insulin Sensitivity Check Index (QUICKI)
This is a cross sectional study where the outcome was measured whenever the test was conducted.
Time frame: 1 year
Oral Glucose Insulin Sensitivity Index (OGIS)
This is a cross sectional study where the outcome was measured whenever the test was conducted.
Time frame: 1 year
Early phase insulin response during OGTT was calculated for the first 30 minutes
This is a cross sectional study where the outcome was measured whenever the test was conducted.
Time frame: 1 year
Area under the curve for incretin hormone
This is a cross sectional study where the outcome was measured whenever the test was conducted.
Time frame: 1 year
Incretin effect
It is estimated by relating the differences in beta cell responses from C peptide between stimulation with oral and intravenous glucose. The incretin effect is estimated by the formula 100 ×(BCOG BCIV)/BCOG).
Time frame: 1 year
Plan to share: Undecided
This study is completed, as verified in Jul 2016. You cannot join it, but the record below documents what was studied.
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RCSI & UCD Malaysia Campus