An observational study in Chronic Obstructive Pulmonary Disease, sponsored by University of Missouri-Columbia. Withdrawn at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2016-09-30.
Sponsored by University of Missouri-Columbia · Observational
Primary objective of this project is to measure the impact of passive control and active control systems on indoor pollution that is directly or indirectly related to ambient air pollution (smog). The first goal will be to measure baseline parameters for 50 homes, including information about the building, ventilation characteristics, pollution levels (indoors and outdoors), and occupant survey information. In a subset of these homes, either passive or active control systems will be installed and the impact of these systems on indoor concentrations. Participants will be enrolled on a rolling basis (5-15 persons studied at a given point in time) over a 16-month period. Participants will be followed for approximately 5 weeks and data obtained at three points in time: at enrollment (day 1 of study), after 1 week (baseline verification) and after four weeks with the control system in the home (at the end of study week 5).
Chronic obstructive pulmonary disease (COPD) is a degenerative lung disease resulting in lower lung function characterized by an obstruction to airflow. COPD is an umbrella term for two disease processes: chronic bronchitis and emphysema. It is currently the 4th leading cause of death in the United States. Approximately 14 million Americans are known to suffer from COPD; however, it is estimated that as many as 24 million Americans may have some form of one or both of the diseases (Centers for Disease Control, 2011). The primary risk factor for developing COPD is cigarette smoking; other factors include exposure to air pollution, occupational dusts and chemicals, and lower socioeconomic status. Poverty has been identified as a risk factor for COPD but the aspects related to poverty that increase the risk of COPD are unclear (GOLD, 2011). Lower education level and household income has been noted to relate to increased severity of COPD (Eisner, Blanc, Omachi, Yelin, Sidney, Katz, et al, 2011). An American Lung Association survey found that over half of those diagnosed with COPD reported that their condition limits their ability to perform activities of daily living, including activities in the home (American Lung Association, 2009). As air pollution can lead to an exacerbation of COPD symptoms and precipitate emergency room visits and hospitalization, minimizing pollution in indoor air may be a key component of disease management and decreasing health care costs.
4,252 studies on the registry are indexed under Pulmonary Disease, Chronic Obstructive; 707 are open to participants now.
Browse Pulmonary Disease, Chronic Obstructive studies →University of Missouri-Columbia is the lead sponsor of 364 studies on the registry; 70 are open to participants now.
Of its 42 completed or terminated interventional studies of FDA-regulated products, 29 (69%) have results posted.
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Study participants will be recruited from pulmonary rehabilitation centers in St. Louis, MO. Potential participants will be screened to ascertain eligibility based on diagnosis and stage of disease progression.
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Exclusion Criteria:
Persons enrolled in the study will have been diagnosed with Stage III or IV COPD and samples of air taken from their home environment.
Change in Air quality measures at week 5
Air samples taken from the home
Time frame: week 5 of study
Change in Borg scale for breathlessness from week 1 to week 5
Scale on which participant rates perceived breathlessness
Time frame: week 1 of study, week 2 of study and week 5 of study
Change in vital signs from week 1 to week 5
Heart rate, respiratory rate, blood pressure, oxygen saturation (SpO2) via pulse oximetry, bedside spirometry
Time frame: week 1 of study, week 2 of study and week 5 of study
Change in Air quality measures from week 1 to week 5
Change in Air quality measures from week 1 to week 5
Time frame: week 1 and week 2 of the study
Plan to share: No
No publications or documents are linked to this record.
The record gives a start of Jan 2013, a primary completion of Jan 2013 and a completion of Jan 2013. It does not say whether these dates are actual or estimated.
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This study is withdrawn, as verified in Sep 2016. You cannot join it, but the record below documents what was studied.
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Pulmonary Disease, Chronic Obstructive →
University of Missouri-Columbia →