An observational study in Maternal; Malnutrition, Infant Malnutrition and Physiological Stress, sponsored by McGill University. Completed. Open to female participants, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-04-28.
Sponsored by McGill University · Observational
This study takes place in rural Mam-Mayan communities of Guatemala characterized by high rates of childhood stunting. It aims to characterize women's exposure to nutrition, infection and psychosocial stressors vs. resilience factors, to evaluate the cumulative impact of maternal-level factors (nutritional, infectious, psychosocial), social factors (autonomy, social support, domestic violence), and household factors (socioeconomic status, food security) on early infant growth, and to evaluate whether maternal cortisol may be a mediator in the vertical transmission of stress.
Grounded in participatory action research and a socio-ecological framework, this mixed-methods, observational study enrolled a longitudinal cohort of 155 women, seen during pregnancy (6-9 mo), early (0-6 wks) and later (4-6 mo) postpartum, and two cross-sectional cohorts (60 early, 56 later postpartum).
Maternal and infant anthropometry was recorded, maternal fecal, urine and saliva samples were collected, and questionnaires were used to explore household factors (socioeconomic status, food security), social factors (autonomy, paternal/social support, domestic violence), and maternal-level factors (nutrition, infection, emotional distress).
Analyses focused on (1) characterizing women's exposure to nutrition, infection and psychosocial stressors vs. resilience factors, (2) describing the maternal diurnal salivary cortisol rhythm in pregnancy and postpartum and explore its association with psychosocial variables, (3) assessing the cumulative impact of maternal-level factors (nutritional, infectious, psychosocial), social factors (autonomy, social support, domestic violence), and household factors (socioeconomic status, food security) on early infant growth, and (4) evaluating whether maternal cortisol may be a mediator in the vertical transmission of stress.
In addition, Photovoice activities involved giving a camera to 23 women from study communities, who documented sources of stress vs. resilience for local women, and shared photo-elicited narratives through six group sessions.
1,277 studies on the registry are indexed under Malnutrition; 230 are open to participants now.
This study's enrollment of 271 is above the median of 206 across 393 observational studies indexed under Malnutrition.
Browse Malnutrition studies →McGill University is the lead sponsor of 249 studies on the registry; 51 are open to participants now.
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Indigenous Mam-Mayan women living in 8 rural hamlets (or communities) in the municipality of San Juan Ostuncalco, in the department of Quetzaltenango, Guatemala.
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Exclusion Criteria:
155 women enrolled in 2nd or 3rd trimester of pregnancy, and seen again, with their infant, at 0-6 wk postpartum, and 4-6 mo postpartum
60 women enrolled at 0-6 wk postpartum and seen once with their infant (cross-sectional)
56 women enrolled at 0-6 wk postpartum and seen once with their infant (cross-sectional)
Infant stunting (Infant height-for-age score)
Infant height-for-age score measured at 0-6 wk
Time frame: 0-6 wk
Infant stunting (Infant height-for-age score)
Infant height-for-age score measured at 4-6 mo postpartum
Time frame: 4-6 mo postpartum
Change in infant HAZ per month
Change in infant HAZ score between 1st (0-6 wk) and 2nd (4-6 mo) visits
Time frame: Change over time (between 0-6wk and 4-6mo)
No study locations are listed for this record.
Plan to share: Undecided
The record gives a start of Jun 2012, a primary completion of Nov 2013 and a completion of Nov 2013. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Apr 2016. You cannot join it, but the record below documents what was studied.
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