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CompletedNCT02754089SomaghWeightUpdated Aug 23, 2018

The Effects of Rhus Coriaria L. on Body Weight

An interventional study of Rhus Coriaria L.(Rhus) and Placebo in Body Weight, sponsored by Shiraz University of Medical Sciences. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-23.

Sponsored by Shiraz University of Medical Sciences · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
50
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as "Somagh" on body weight.

Read the detailed description

Rhus coriaria L.(Rhus) is a well-known spice widely consumed in the world which has also been utilized extensively for medicinal purposes. The antioxidant components of this plant made it a favorable target for laboratory and animal studies in different conditions such as oxidative stress cytotoxicity, diabetes and hyperlipidemia. Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrheic, antiseptic, anorexic and antihyperglycemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.

02

Conditions studied

  • Body Weight

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Keywords

  • Body weight changes
  • Medicine, Traditional
  • Herbal medicine
  • Rhus
  • Waist Circumference
  • Waist-Hip Ratio
  • Body mass index
03

In context

Body Weight

1,223 studies on the registry are indexed under Body Weight; 131 are open to participants now.

This study's enrollment of 50 is below the median of 64 across 947 interventional studies indexed under Body Weight.

Browse Body Weight studies →

Lead sponsor

Shiraz University of Medical Sciences is the lead sponsor of 129 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Body mass index (BMI) >= 25 kg/m2

Exclusion criteria

Exclusion Criteria:

  • Diabetes mellitus
  • Hypo. or hyperthyroidism
  • Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure
  • Use of drugs: Weight lowering agents, glucocorticoids, Oral contraceptive pills.
  • Pregnancy
  • History of allergic reaction to Somagh
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
50 participants (actual)

Study arms

  • Experimental
    Rhus

    500 mg twice daily after meal for 6 weeks

    Drug: Rhus Coriaria L.(Rhus)

  • Placebo comparator
    Placebo

    500 mg twice daily after meal for 6 weeks

    Drug: Placebo

Interventions

  • DrugRhus Coriaria L.(Rhus)

    500 mg twice daily after meals for 6 weeks

    Also known as: Somagh

  • DrugPlacebo

    500 mg twice daily after meals for 6 weeks

06

What researchers measure

Primary outcomes

  1. Body Mass Index

    Time frame: 6 weeks

Secondary outcomes

  1. Waist Circumference (cm)

    Time frame: 6 weeks

  2. Hip Circumference (cm)

    Time frame: 6 weeks

  3. Leptin (ng/ml)

    Time frame: 6 weeks

  4. Insulin (mU/l)

    Time frame: 6 weeks

  5. Fasting Blood Glucose (mg/dl)

    Time frame: 6 weeks

  6. Number of patients with adverse event

    Time frame: 6 weeks

07

Study locations

1 site
  • Shahid Motahhari Clinic, Shiraz University of Medical Sciences
    Shiraz, Fars, Iran, Islamic Republic of
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 23, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02754089
Lead sponsor
Shiraz University of Medical Sciences
Responsible party
Mesbah Shams, MD (Associate professor of Internal Medicine & Endocrinology, Shiraz University of Medical Sciences) — Principal investigator
First posted
Apr 28, 2016
Start date
May 2016
Primary completion
Sep 2016
Completion
Sep 2016
Last update
Aug 23, 2018

Study contacts

Mojtaba Heydari, MD
principal investigator · Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
Gholamhossein Ranjbar Omrani, MD
study chair · Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences
Zahra Hajmohammadi, MD
principal investigator · Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2016. You cannot join it, but the record below documents what was studied.

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