ClinicalTrials.gg
CompletedNCT02733549Updated Apr 12, 2016

Is The Sudden Onset of Dizziness A Symptom of Acute Liver Dysfunction?

An observational study in Dizziness, sponsored by Adiyaman University Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-04-12.

Sponsored by Adiyaman University Research Hospital · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
198
Ages
18 Years to 55 Years
Sex
All
01

Study summary

Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of liver function tests for patients with SOD in the ED, and a cost analysis of liver function tests.

Read the detailed description

Dizziness is one of the most common complaints among patients admitted to the emergency department (ED). In most cases, the etiology remains unclear. Dizziness has a broad differential diagnosis. The initial symptoms of ALD can include many general complaints. The diagnosis of acute liver dysfunction (ALD) can usually be made by initial symptoms, physical examination, and biochemical tests, including liver function tests (LFTs) with high sensitivity and specificity. LFTs include albumin, bilirubin, coagulation factors (Activated Partial Thromboplastin Time (aPTT) and International Normalized Ratio (INR)), and liver enzymes, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphates (ALP), and y-glutamyl transpeptidase (GGT), which are marker of hepatic damage. Aim of this study is to investigate whether SOD is a symptom of ALD, the necessity of LFTs for patients with SOD in the ED, and a cost analysis of LFTs.

02

Conditions studied

  • Dizziness

Browse trials for

03

In context

Dizziness

285 studies on the registry are indexed under Dizziness; 62 are open to participants now.

This study's enrollment of 198 is above the median of 122 across 64 observational studies indexed under Dizziness.

Browse Dizziness studies →

Lead sponsor

Adiyaman University Research Hospital is the lead sponsor of 49 studies on the registry; 9 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 55 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Adult patients with sudden onset dizziness admitted to emergency department.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

1. Adult patients who were experiencing sudden onset dizziness of unknown etiology for the first time were included in the study

Exclusion criteria

Exclusion Criteria:

  1. Patients with a history of chronic diseases such as any liver disease,diabetes mellitus, hypertension,congestive heart failure, hepatitis B or C infection
  2. Patients with any central dizziness attacks
  3. Patients with hemodynamically unstable and emesis;
  4. Patients receiving drugs that could affect liver function tests, such as, acetaminophen, antibiotics, oral contraceptives, antihypertensive drugs (e.g., angiotensinconverting enzyme inhibitors), or hormones (e.g.,estrogen)
  5. Patients who was experienced dizziness with systemic diseases
  6. Patients with any neurological disorders
  7. Patient who do not want to participate in the study
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
198 participants (actual)
Target follow-up
3 Months
Patient registry
Yes

Groups and cohorts

  • patient

    Patients with sudden onset dizziness (SOD) analysed LFTs

    Other: LFTs

  • control

    The control group with 98 healthy volunteer analysed LFTs

    Other: LFTs

Interventions

  • OtherLFTs

    A single 5-ml peripheral venous blood sample was collected from each participant. Serum ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, and albumin level, Platelet count, INR and aPTT were analyzed.

    Also known as: liver function tests

06

What researchers measure

Primary outcomes

  1. LFTs serum levels by biochemical method ALT, AST, ALP, GGT, total bilirubin, conjugated bilirubin, albumin, INR, aPTT, and Platelet count (PC)

    The serum levels of LFTs will obtained by the laboratory analysis of blood samples of each participant.

    Time frame: 5 months

Secondary outcomes

  1. The cost calculation for the LFTs

    The cost for the LFTs will be calculated with financial data in invoices which will obtained from the hospital invoicing service.

    Time frame: 5 months

07

Study locations

1 site
  • Adiyaman University Research Hospital
    Adıyaman, Central 02000, Turkey (Türkiye)
08

References and documents

Publications

  • Giannini EG, Testa R, Savarino V. Liver enzyme alteration: a guide for clinicians. CMAJ. 2005 Feb 1;172(3):367-79. doi: 10.1503/cmaj.1040752. PubMed 15684121 ↗
  • Newman-Toker DE, Hsieh YH, Camargo CA Jr, Pelletier AJ, Butchy GT, Edlow JA. Spectrum of dizziness visits to US emergency departments: cross-sectional analysis from a nationally representative sample. Mayo Clin Proc. 2008 Jul;83(7):765-75. doi: 10.4065/83.7.765. PubMed 18613993 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 12, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02733549
Lead sponsor
Adiyaman University Research Hospital
Responsible party
Umut Gulacti (principal investigator, Adiyaman University Research Hospital) — Principal investigator
First posted
Apr 11, 2016
Start date
Sep 2012
Primary completion
Mar 2013
Completion
Mar 2013
Last update
Apr 12, 2016

Study contacts

Umut Gulacti
principal investigator · Adiyaman University Medical Faculty

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2016. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion