An observational study in Vascular Endothelial Growth Factor Overexpression, sponsored by IVI Bilbao. Completed at 3 sites in Spain. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-08-01.
Sponsored by IVI Bilbao · Observational
The hypothesis is growing semen samples with plasma rich in growth factors (PRGF), because it could improve sperm motility in patients subsidiary TRA, ultimately improving pregnancy rates.
Platelet growth factors are a group of proteins involved in cellular communication modifying biological responses. Obtaining plasma rich in growth factors is already widespread and simple protocol technique that is being used in various areas of medicine with superb results. Described many of the growth factors present in the PRGF are related to sperm parameters, especially motility The described effects have been studied in mammalian and each growth factor individually. PRGF contains a pool of growth factors and therefore be interesting to analyze their effect on various sperm parameters.
One of those parameters is very important for fertilization sperm motility, since the lack of it will prevent displacement by the cervix to meet the egg in the fallopian tube.
IVI Bilbao is the lead sponsor of 9 studies on the registry; none are open to participants now.
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Prospective study of 58 candidates for sperm donors clinic IVI Bilbao.
Exclusion Criteria:
Prospective study of 58 candidates for sperm donors clinic IVI Bilbao.
Biological: PRGF in candidates for sperm donors
PRGF application on seminal aliquots will be conducted at different concentrations assessing sperm motility.
Evaluate the percentage of motile sperm adding PRGF versus those samples that growth factors were not added
Within concerted donor visits in IVI Bilbao will be held: * Removing Blood 9 mL of blood to obtain plasma rich in factors growth * Seminogram to analyze all semen parameters according to the criteria of the WHO (2010), paying particular attention to sperm motility. * Sperm vitality will be analyzed before and after treatment with PRGF. PRGF application on the seminal aliquots will be conducted at different concentrations assessing sperm motility.
Time frame: 6 months
Plan to share: Yes — share data to BTI
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This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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