A Phase 3 interventional study of Blastocyte Transferring and Embryo Transferring in Infertility, sponsored by Royan Institute. Completed at 1 site in Iran, Islamic Republic of. Open to female participants aged 16 Years to 37 Years. Per ClinicalTrials.gov, last updated 2021-05-12.
Sponsored by Royan Institute · Phase 3, Interventional, and Treatment
Recent improvements in cell culture systems have led to a shift in in vitro fertilization (IVF) practice from early cleavage stage embryo transfer (ET) to blastocyst transfer. Blastocyst culture and transfer could theoretically provide better synchronization between the embryo and the uterine endometrium. The purpose of this study is comparing pregnancy rates and implantation rate following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage embryos.
The proposal of this study approved by our institutional review boards and institution's ethical committee, and all participants will sign a written consent before enter to study. All patients will be randomly divided into two groups of thawed cleavage embryo transfers and transfers of blastocysts from thawed cleavage embryos. Embryos will be transferred in hormone replacement cycles. Preparation of the endometrium will be started in the second day of menstruation and will be continued according to their transfer type (blastocyst or cleavage). βhCG will be assessed 14 days after embryo transfer. Treatment cycle outcomes will be compared between 2 groups.
2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.
This study's enrollment of 220 is above the median of 120 across 1,698 interventional studies indexed under Infertility.
Browse Infertility studies →Royan Institute is the lead sponsor of 92 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
The infertile women who underwent intra- uterus transferring of blastocyst from thawed cleavage embryo
Procedure: Blastocyte Transferring
The infertile women who underwent intra- uterus transferring of thawed cleavage embryo.
Procedure: Embryo Transferring
Intra-uterine transferring of blastocyst from thawed cleavage embryo in infertile women.
Inta-uterine transferring of thawed cleavage embryo transfer in infertile women.
Pregnancy Rate
Evaluation of pregnancy rate in women 4 weeks after embryos transfer (ET).
Time frame: 4weeks
Miscarriage Rate
Evaluation the miscarriage rate in women 14 days after embryo transfer (ET) with BHCG titration.
Time frame: 14 days
Implantation Rate
Evaluation the implantation rate in women 14 days after embryo transfer (ET) with BHCG titration..
Time frame: 14 days
Ongoing pregnancy rate
Evaluation the ongoing pregnancy rate in women 14 days after embryo transfer (ET) with BHCG titration..
Time frame: 14 days
This study is completed, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.
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Royan Institute