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Status unknownNCT02610985Updated Apr 3, 2018

2-D and 3-D Laparoscopic Hysterectomy

An interventional study of 3-D laparoscopy and 2-D laparoscopy in Fibroma, Bleeding, sponsored by Zealand University Hospital. Status unknown at 1 site in Denmark. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-04-03.

Sponsored by Zealand University Hospital · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Apr 2018), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
400
Allocation
Randomized
Ages
18 Years and older
Sex
Female
01

Study summary

Background:

No randomised trials have been conducted, and only a single retrospective study exists comparing 3D and 2D laparoscopic hysterectomy. In that study, operative time for hysterectomy was significantly lower for 3D compared to 2D conventional laparoscopy. Complication rates were similar for the two groups. Thus, although one out of nine women is hysterectomized and although laparoscopy is one of the recommended routes of surgery, evidence whether to choose 2D laparoscopy, 3D laparoscopy is sparse.

Objective:

To compare pain and recurrence to usual activity level. Secondary to compare complications during the operation, postoperative complications, time to return to work, length of hospital stay and operative time.

Design:

Investigator-initiated, blinded, randomised controlled trial.

Intervention description:

Operative procedures follow the same principles and the same standard whether the surgeon's vision is 2D or 3D.

Trial size Roskilde/Herlev Hospital, Denmark:

200 patients in each arm of the study.

02

Conditions studied

  • Fibroma, Bleeding

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Keywords

  • Imaging, Three-Dimensional
  • Hysterectomy
  • laparoscopic hysterectomy
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • All patients referred for laparoscopic hysterectomy with or without bilateral salpingectomy or bilateral salpingooophorectomy for benign indications.

Exclusion criteria

Exclusion Criteria:

  • Women not suitable for laparoscopic hysterectomy including:

    • Ultrasound appraisal of uterus weight > 1000 gram
    • Need for prolapse surgery and therefore indication for vaginal hysterectomy.
  • Inability to give informed consent
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Investigator, Outcomes assessor)
Enrollment
400 participants (estimated)

Study arms

  • Active comparator
    2-Dimensional laparoscopic hysterectomy

    traditional 2-D laparoscopy

    Device: 2-D laparoscopy

  • Experimental
    3-Dimensional laparoscopic hysterectomy

    experimental 3-D laparoscopy

    Device: 3-D laparoscopy

Interventions

  • Device3-D laparoscopy

    3-D laparoscopy

  • Device2-D laparoscopy

    2-D laparoscopy

05

What researchers measure

Primary outcomes

  1. Score on SF 36 psychical health survey 6 weeks after surgery

    Time frame: 6 weeks

  2. Pain (VAS score) assessed immediately at return to the gynaecological unit (about 5 hours postoperatively) and (VAS score) in the morning days 1-3 postoperatively.

    Time frame: 3 days

Secondary outcomes

  1. Major complications during the operation, postoperative complications

    Time frame: 6 weeks

  2. Minor complications during the operation, postoperative complications

    Time frame: 6 weeks

  3. Score on SF 36 mental health survey 6 weeks after surgery

    Time frame: 6 weeks

  4. Length of hospital stay

    Time frame: 6 weeks

  5. Operative time

    Time frame: 4 hours

06

Study locations

1 of 1 sites recruiting
  • Sjaellands Univercety Hospital
    Roskilde, Zealand 4000, Denmark
    Recruiting
07

References and documents

Publications

  • Hoffmann E, Bennich G, Larsen CR, Lindschou J, Jakobsen JC, Lassen PD. 3-dimensional versus conventional laparoscopy for benign hysterectomy: protocol for a randomized clinical trial. BMC Womens Health. 2017 Sep 7;17(1):76. doi: 10.1186/s12905-017-0434-7. PubMed 28882141 ↗
08

Registry details

Key details

Study ID
NCT02610985
Lead sponsor
Zealand University Hospital
Responsible party
Elise Hoffmann (MD, Zealand University Hospital) — Principal investigator
First posted
Nov 20, 2015
Start date
Sep 2016
Primary completion
Dec 2018 (estimated)
Last update
Apr 3, 2018

Study contacts

Elise Hoffmann, MD
Contact
elisehoffmann78@gmail.com
+45 20252017

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Apr 2018. You cannot join it, but the record below documents what was studied.

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