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Status unknownNCT02564731Updated Jan 9, 2017

Prognosis of Bronchiectasis in Children--A Multicenter Prospective Cohort Study

An observational study in Bronchiectasis, sponsored by Baoping XU. Status unknown at 1 site in China. Open to participants aged Up to 18 Years. Per ClinicalTrials.gov, last updated 2017-01-09.

Sponsored by Baoping XU · Observational

The sponsor has not verified this record recently (last verified Jan 2017), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
300
Ages
Up to 18 Years
Sex
All
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Study summary

This prospective cohort study is designed to observe of the effect of intervention therapy on the long-term prognosis of children with bronchiectasis. The main purpose of the study was to evaluate the degree of deterioration of lung function, to observe and compare the quality of life, the time of pulmonary exacerbation, and the changes of lung image.

Read the detailed description

All enrolled patients are followed up for half a year, 1 years, 2 years, 3 years, 4 years, 5 years, while observation of pulmonary function, symptoms, signs, quality of life, the times of acute pulmonary exacerbation, and the changes of lung image are performed.

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Conditions studied

  • Bronchiectasis

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Keywords

  • children
  • prognosis
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In context

Bronchiectasis

368 studies on the registry are indexed under Bronchiectasis; 104 are open to participants now.

This study's planned enrollment of 300 is above the median of 160 across 132 observational studies indexed under Bronchiectasis.

Browse Bronchiectasis studies →

Lead sponsor

Baoping XU is the lead sponsor of 2 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Up to 18 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Children who was confirmed diagnosis as bronchiectasis at the certain hospitals (sponsor and collaborators)

Eligibility criteria

Inclusion Criteria:A included patient must be coincident at least one point of the four items of high-resolution computed tomography (HRCT) manifestations.

  • Internal bronchial diameter greater than the accompanying pulmonary artery.
  • lack of bronchial tapering
  • bronchi visible in the peripheral 1cm of lung
  • bronchial diameter greater than adjacent segmental bronchi

Exclusion Criteria:Subject will be excluded if she or he has one of the following

  • It is unable or doesn't agree to accept the follow-up process
  • undergoing trial for other medications or instruments.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
300 participants (estimated)
Patient registry
No
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What researchers measure

Primary outcomes

  1. Change from baseline in lung function on the spirometry

    forced expiratory volume at one second (FEV1) in Liter

    Time frame: 5 years

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Study locations

1 of 1 sites recruiting
  • Beijing Children'S Hospital
    Beijing, Beijing 100045, China
    • baoping xu · Contact
    Recruiting
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References and documents

Publications

  • Karakoc GB, Yilmaz M, Altintas DU, Kendirli SG. Bronchiectasis: still a problem. Pediatr Pulmonol. 2001 Aug;32(2):175-8. doi: 10.1002/ppul.1104. PubMed 11477735 ↗
  • Munro KA, Reed PW, Joyce H, Perry D, Twiss J, Byrnes CA, Edwards EA. Do New Zealand children with non-cystic fibrosis bronchiectasis show disease progression? Pediatr Pulmonol. 2011 Feb;46(2):131-8. doi: 10.1002/ppul.21331. Epub 2010 Aug 17. PubMed 20717910 ↗
  • Twiss J, Stewart AW, Byrnes CA. Longitudinal pulmonary function of childhood bronchiectasis and comparison with cystic fibrosis. Thorax. 2006 May;61(5):414-8. doi: 10.1136/thx.2005.047332. Epub 2006 Feb 7. PubMed 16467074 ↗
  • Murray MP, Pentland JL, Hill AT. A randomised crossover trial of chest physiotherapy in non-cystic fibrosis bronchiectasis. Eur Respir J. 2009 Nov;34(5):1086-92. doi: 10.1183/09031936.00055509. Epub 2009 Jun 18. PubMed 19541717 ↗
  • Davies G, Wilson R. Prophylactic antibiotic treatment of bronchiectasis with azithromycin. Thorax. 2004 Jun;59(6):540-1. No abstract available. PubMed 15170047 ↗
  • Valery PC, Morris PS, Byrnes CA, Grimwood K, Torzillo PJ, Bauert PA, Masters IB, Diaz A, McCallum GB, Mobberley C, Tjhung I, Hare KM, Ware RS, Chang AB. Long-term azithromycin for Indigenous children with non-cystic-fibrosis bronchiectasis or chronic suppurative lung disease (Bronchiectasis Intervention Study): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med. 2013 Oct;1(8):610-620. doi: 10.1016/S2213-2600(13)70185-1. Epub 2013 Sep 17. Erratum In: Lancet Respir Med. 2015 Aug;3(8):e29. doi: 10.1016/S2213-2600(15)00277-5. PubMed 24461664 ↗
  • Gaylor AS, Reilly JC. Therapy with macrolides in patients with cystic fibrosis. Pharmacotherapy. 2002 Feb;22(2):227-39. doi: 10.1592/phco.22.3.227.33544. PubMed 11837560 ↗
  • WANG Hao，XU Bao-ping，LIU Xiu-yun，HU Ying-hui，REN Yi-xin，SHEN Kun-ling. Clinical characteristics and follow-up of bronchiectasis in children. Chinese Journal of Practical Pediatrics, 2014;29 (12):936-939
  • CHEN Jun, DUO Li-kun, WANG Xiao-feng. Clinical analysis of 22 children with bronchiectasis. J Clin Pediatr, 2012, 30(1):51-54.
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 9, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02564731
Lead sponsor
Baoping XU
Collaborators
Wuhan women and children's health care center, Children's Hospital of Chongqing Medical University, Yuying Children's Hospital of Wenzhou Medical University, Changchun Children's Hospital, Shenzhen Children's Hospital, Jiangxi Province Children's Hospital, Shanghai Children's Medical Center, First Affiliated Hospital of Guangxi Medical University, Tianjin Children's Hospital, The First Affiliated Hospital of Xiamen University, Children's Hospital of Fudan University, The Affiliated Hospital Of Guizhou Medical University, Shanxi Provincial Maternity and Children's Hospital
Responsible party
Baoping XU (Chief of Respiratory Department, Beijing Children's Hospital) — Sponsor-investigator
First posted
Oct 1, 2015
Start date
Jun 2016
Primary completion
Mar 2022 (estimated)
Completion
Mar 2022 (estimated)
Last update
Jan 9, 2017

Study contacts

Baoping Xu, MD,PhD
Contact
xubaopingbch@163.com
861059616308
Kunling Shen, MD,PhD
study director · Beijing Children's Hospital of Capital Medical University, China
Baoping Xu, MD,PhD
principal investigator · Beijing Children's Hospital of Capital Medical University, China
Xiaoxia Peng, MD,PhD
principal investigator · Beijing Children's Hospital of Capital Medical University, China

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2017. You cannot join it, but the record below documents what was studied.

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