An interventional study of Clomifene citrate ( clomid 50 mg ) and Amlodipine in Female Infertility Associated With Anovulation, sponsored by Ahmed Fathy Ali Mohamed Ghanem. Completed. Open to female participants aged 20 Years to 35 Years. Per ClinicalTrials.gov, last updated 2016-03-25.
Sponsored by Ahmed Fathy Ali Mohamed Ghanem · Not applicable, Interventional, and Treatment
On the basis of the current study, amlodipine seems to be a promising drug on improving uterine, ovarian blood flow, size of pre-ovulatory follicle, midluteal progesterone level and pregnancy outcome in patients with pco.
To know if amlodipine has vasodilator effect on ovarian ar. In pco patient.
Infertility secondary to polycystic ovary , The choice of polycystic ovary patients will be according to the Rotterdam consensus workshop (Rotterdam, 2004), and the diagnosis of polycystic ovary by ultrasonography will be made according to Adams et al. criteria which are the most often cited (Adams et al., 1985).The Rotterdam criteria as follows:
Exclusion Criteria:
Amlodipine 5mg tablet and Clomifene citrate 50 mg tablet once by mouth daily at morning starting from day number 5 of menstrual cycle till day number 9.
Drug: Clomifene citrate ( clomid 50 mg ) · Drug: Amlodipine
Clomifene citrate 50mg and once daily at morning starting from day number 5 of menstrual cycle till day number 9
Drug: Clomifene citrate ( clomid 50 mg )
Also known as: clomid ( 50 mg )
Also known as: Norvasc 5mg
change in ovarian artery perfusion
peak systolic velocity ( psv ) measured by doppler u/s
Time frame: day number five and day number 9 of menstrual cycle
Number of mature follicle
by vaginal u/s
Time frame: day 14 of menstrual cycle
endometrial thickening
by vaginal u/s
Time frame: day number five and day number 9 of menstrual cycle
No study locations are listed for this record.
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