An observational study in Fluid Responsiveness, sponsored by University of Aarhus. Completed at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-02-10.
Sponsored by University of Aarhus · Observational
Fluids are generally administered to patients in order to improve circulation. However, fluids do not always improve circulation and fluids have side effects. Unfortunately, it is difficult to predict whether fluid administration improves the circulation, i.e. it is difficult to predict fluid responsiveness The overall aim of this observational study is to investigate if analysis of spontaneously occuring extra systoles can give the answer: The second beat in the extra systole - the post ectopic beat - is a normal sinus beat but it has experienced the compensatory pause, i.e. this beat is associated with increased filling time and in turn associated with increased filling. As such, the post ectopic beat shows how the heart responds to increased filling. Therefore, the hypothesis of this study is that the hemodynamic response to the increased filling at the post ectopic beat (compared with sinus beats) can predict fluid responsiveness
79 studies on the registry are indexed under Cardiac Complexes, Premature; 13 are open to participants now.
This study's enrollment of 26 is below the median of 100 across 37 observational studies indexed under Cardiac Complexes, Premature.
Browse Cardiac Complexes, Premature studies →University of Aarhus is the lead sponsor of 1,274 studies on the registry; 183 are open to participants now.
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Critically ill patients admitted to a University Hospital intensive care unit
Exclusion Criteria:
Change in stroke volume (SV) following fluid administration. A positive fluid response is defined as a 15% or more increase in SV
A positive fluid response is defined as a 15% or more increase in SV. From the arterial pressure curve, post ectopic changes (comparing with 10 preceding sinus beats) in systolic blood pressure and pre-ejection period will be derived and used to predict the fluid response. Time frame used is the 30 minutes prior to the volume expansion (from t = -30 min to t = 0 min)
Time frame: Change in SV from immediately before fluid infusion (t=0 min) to immediately after fluid administration (t < 30 min for crystalloid infusions; t < 75 min for colloid infusions)
This study is completed, as verified in May 2016. You cannot join it, but the record below documents what was studied.
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University of Aarhus