An interventional study of Cranberry 320 and Cranberry 640 in Healthy Men, sponsored by Heinrich-Heine University, Duesseldorf. Completed at 1 site in Germany. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-11-03.
Sponsored by Heinrich-Heine University, Duesseldorf · Not applicable, Interventional, and Prevention
Accumulating evidence from epidemiological and human intervention studies indicates that the cardiovascular health benefits of diets rich in fruits and vegetables are (in part) related to their (poly)phenol content. Cranberries are rich in (poly)phenols compounds, in particular anthocyanins, but also phenolic acids. At present, a small number of randomized controlled trials investigating the effects of berry (poly)phenols on validated surrogate markers of cardiovascular disease risk has shown promising results. However, to date, very few human studies have specifically investigated the effects of cranberry (poly)phenols on cardiovascular function in healthy subjects. To our knowledge, no study has investigated the time and intake-dependent effect of cranberry consumption on vascular function in healthy subjects. This information is necessary for the planning of long-term studies aiming to assess the potential beneficial effects of cranberries, using optimal amounts at optimal time points. Therefore, this study aims to investigate the potential role of cranberry (poly)phenols in the modulation of vascular function by monitoring changes in vascular function together with the major (poly)phenol derivatives/metabolites in plasma and urine.
Heinrich-Heine University, Duesseldorf is the lead sponsor of 174 studies on the registry; 52 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Dietary Supplement: Cranberry beverage with 320 mg of (poly)phenols Acute intake of 500 mL (1x daily)
Dietary Supplement: Cranberry 320
Dietary Supplement: Cranberry beverage with 640 mg of (poly)phenols Acute intake of 500 mL (1x daily)
Dietary Supplement: Cranberry 640
Dietary Supplement: Cranberry beverage with 960 mg of (poly)phenols Acute intake of 500 mL (1x daily)
Dietary Supplement: Cranberry 960
Dietary Supplement: Cranberry beverage with 1280 mg of (poly)phenols Acute intake of 500 mL (1x daily)
Dietary Supplement: Cranberry 1280
Dietary Supplement: Cranberry beverage with 1600 mg of (poly)phenols Acute intake of 500 mL (1x daily)
Dietary Supplement: Cranberry 1600
Placebo comparator: Cranberry deprived supplement Acute intake of 500 mL (1x daily)
Dietary Supplement: Cranberry deprived supplement
Dietary Supplement: Cranberry beverage with 320 mg of (poly)phenols Acute intake of 500 mL (1x daily)
Dietary Supplement: Cranberry beverage with 640 mg of (poly)phenols Acute intake of 500 mL (1x daily)
Dietary Supplement: Cranberry beverage with 960 mg of (poly)phenols Acute intake of 500 mL (1x daily)
Dietary Supplement: Cranberry beverage with 1280 mg of (poly)phenols Acute intake of 500 mL (1x daily)
Dietary Supplement: Cranberry beverage with 1600 mg of (poly)phenols Acute intake of 500 mL (1x daily)
Cranberry deprived supplement Acute intake of 500 mL (1x daily)
Endothelial function
measured by Flow mediated dilation at 1, 2, 4, 6 and 8 hours after intake
Time frame: Baseline, on week 1, 2, 3, 4 and 5 postconsumption
pulse wave velocity
measured by SphygmoCor at 0, 1, 2, 4, 6 and 8 hours after intake
Time frame: Baseline, on week 1, 2, 3, 4 and 5 postconsumption
Central blood pressure
measured by SphygmoCor at 0, 1.5, 4, 6 and 8 hours after intake
Time frame: Baseline, on week 1, 2, 3, 4 and 5 postconsumption
Peripheral blood pressure
measured by automatic sphygmomanometer at 0, 1, 2, 4, 6 and 8 hours after intake
Time frame: Baseline, on week 1, 2, 3, 4 and 5 postconsumption
Heart Rate
measured by SphygmoCor 0, 1, 2, 4, 6 and 8 hours after intake
Time frame: Baseline, on week 1, 2, 3, 4 and 5 postconsumption
Plasma (poly)phenol metabolites
measured by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF MS) at 0,1, 2, 4, 6, 8 and 24 hours after intake
Time frame: Baseline, on week 1, 2, 3, 4 and 5 postconsumption
Urinary (poly)phenol metabolites
measured by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF MS) at 0, 8 and 24 hours after intake
Time frame: Baseline, on week 1, 2, 3, 4 and 5 postconsumption
This study is completed, as verified in Nov 2015. You cannot join it, but the record below documents what was studied.
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Heinrich-Heine University, Duesseldorf