An observational study in Obesity and Appetite, sponsored by University of Washington. Completed at 1 site in United States. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-10-27.
Sponsored by University of Washington · Observational
Scientists are examining the genetic and environmental influences on appetite and weight gain. The main purpose of this study is to look at how genetic and environmental factors may influence how the brain regulates appetite and food intake. Understanding how the brain regulates appetite and food intake may eventually lead to new ways to help people avoid obesity or lose weight.
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's enrollment of 122 is close to the median of 135 across 1,283 observational studies indexed under Obesity.
Browse Obesity studies →University of Washington is the lead sponsor of 1,397 studies on the registry; 225 are open to participants now.
Of its 154 completed or terminated interventional studies of FDA-regulated products, 132 (86%) have results posted.
Counted across the registry records on this site, refreshed daily.
Monozygotic and dizygotic twins recruited from the University of Washington Twin Registry
Exclusion Criteria:
Device: Functional Magnetic Resonance Imaging · Radiation: Dual Energy X-ray absorptiometry · Other: Questionnaires · Other: Mood and Appetite Ratings · Other: Test Meals · Other: Computer Tests · Procedure: Intravenous Catheter (IV) placement
Device: Functional Magnetic Resonance Imaging · Radiation: Dual Energy X-ray absorptiometry · Other: Questionnaires · Other: Mood and Appetite Ratings · Other: Test Meals · Other: Computer Tests · Procedure: Intravenous Catheter (IV) placement
Measure brain activity.
Also known as: fMRI
Body composition measurements.
Also known as: DXA
Questionnaires related to: health, weight, sleep, mood, dietary habits, attitudes towards eating, how you describe yourself.
Answer questions about how you are feeling at the moment.
Breakfast, a snack, and lunch provided during study visit.
Perform a series of computer tests to determine reaction time.
Blood samples collected throughout regular intervals during the study visit day to measure levels of hormones involved in regulating appetite and body weight. We will also determine if twins are fraternal or identical and will examine DNA to see if participants carry two genes that affect appetite or body weight, the FTO gene and the MC4R gene.
Meal-induced nutrient and hormonal changes in plasma (insulin, GLP-1, ghrelin, glucose)
Time frame: Baseline
Brain activation during fMRI in satiety-related regions
Time frame: Baseline
Body composition: fasting leptin and dual energy X-ray absorptiometry (DXA)
Time frame: Baseline
DNA evaluation of FTO genotypes
Time frame: Baseline
Objective satiety: caloric and macronutrient intake
Time frame: Baseline
Subjective satiety: visual analog scale (VAS) scores and appeal ratings
Time frame: Baseline
This study is completed, as verified in Oct 2017. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Washington