A Phase 4 interventional study of nerve block with ropivacaine and nerve block with ropivacaine and with saline in Knee Arthroplasty, Total, sponsored by Bispebjerg Hospital. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-06-09.
Sponsored by Bispebjerg Hospital · Phase 4, Interventional, and Treatment
The investigators aimed to evaluate the efficacy of selective low volume ultrasound-guided blockades of the saphenous and obturator nerves on dynamic and rest pain 24-hours post-operatively for patients undergoing unilateral primary total knee arthroplasty.
A femoral nerve block is the recommended strategy in many surgical centers to supplement multimodal analgesic regime following total knee arthroplasty (TKA) (i.e. both for spinal and general anesthesia). However, a femoral nerve block will often result in quadriceps paralysis, and this will increase the risk for the patient to fall as long as the femoral block have effect. Thus, the search for sensory nerve blocks to stop pain after TKA is a very interesting topic. The saphenous nerve is a purely sensory nerve, and the posterior branch of the obturator nerve is a mixed nerve, where the motor component only affects part of the adductor major muscle.
Bispebjerg Hospital is the lead sponsor of 281 studies on the registry; 29 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
5 ml of ropivacaine 0.75% for the saphenous nerve and 10 ml of ropivacaine 0,75% for the obturator nerve block. Ropivacaine 0.75% for nerve blockades for both nerves mentioned.
Drug: nerve block with ropivacaine
5 ml of ropivacaine 0.75% for the saphenous nerve and 10 ml of isotonic saline for the obturator nerve block. Ropivacaine 0.75% for the saphenous nerve block and saline for the obturator nerve block
Drug: nerve block with ropivacaine and with saline
5 ml of isotonic saline for the saphenous nerve and 10 ml of isotonic saline for the obturator nerve block. Saline for nerve blockades for both nerves mentioned.
Drug: nerve block with saline
Ultrasound guided nerve blocks of the saphenous and obturator nerve, posterior branch with ropivacaine 0.75% for both nerve branches
Also known as: Saphenous and obturator nerve block with ropivacaine
nerve blocks of the saphenous nerve with ropivacaine 0.75% and obturator nerve, posterior branch with saline
Also known as: Saph block with ropivacaine and obtur block with saline
Ultrasound guided nerve blocks of the saphenous and obturator nerve, posterior branch with saline for both nerve branches
Also known as: saphenous and obturator nerve block with saline
Dynamic pain (pain upon movement) quantified as area-under-the-curve (AUC) 24-hours post-operatively
NRS 0-10
Time frame: 24 hours
Pain at rest quantified as area-under-the-curve (AUC) 24-hours post-operatively
NRS 0-10
Time frame: 24 hours
Total opioid consumption
mg
Time frame: 24 hours
Nausea and vomiting
NRS 0-10
Time frame: 24 hours
Time to first mobilization
hours
Time frame: 24 hours
Length of stay in recovery and hospital
hours
Time frame: 72 hours
Number of clinical complications
total number
Time frame: 72 hours
No study locations are listed for this record.
This study is completed, as verified in Jun 2015. You cannot join it, but the record below documents what was studied.
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Bispebjerg Hospital