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CompletedNCT02442232Updated Aug 26, 2016

Hemodynamic Changes After Anesthesia With Propofol: Study of Biomarkers

An observational study in Hemodynamic Responses to Propofol, sponsored by Conselho Nacional de Desenvolvimento Científico e Tecnológico. Completed. Open to participants aged 40 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-08-26.

Sponsored by Conselho Nacional de Desenvolvimento Científico e Tecnológico · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
65
Ages
40 Years to 80 Years
Sex
All
01

Study summary

The purpose of this study is to evaluate biomarkers affecting the hemodynamic responses to propofol. Particularly, the investigators will assess the effects of polymorphisms in NOS3 and PRKCA genes on hemodynamic responses to propofol and the effects of these polymorphisms on biomarkers related to nitric oxide after propofol anesthesia. In addition, the investigators will evaluate the effects of propofol anesthesia on biomarkers related to nitric oxide in hypertensive patients chronically treated with angiotensin-converting enzyme inhibitors.

02

Conditions studied

  • Hemodynamic Responses to Propofol
03

In context

Lead sponsor

Conselho Nacional de Desenvolvimento Científico e Tecnológico is the lead sponsor of 2 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
40 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients under propofol anesthesia

Inclusion criteria

  • ASA I or II
  • BMI lower 30 kg/m2

Exclusion criteria

Exclusion Criteria:

  • Severe hypertension
  • Previous stroke
  • Previous infarction
  • Uncontrolled respiratory, renal, hepatic and hematological diseases.
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
65 participants (actual)
Patient registry
No

Groups and cohorts

  • Normotensive
  • Hypertensive taking ACEi
  • Hypertensive not taking ACEi
06

What researchers measure

Primary outcomes

  1. Systolic blood pressure

    Time frame: 10 minutes

  2. Diastolic blood pressure

    Time frame: 10 minutes

  3. Mean blood pressure

    Time frame: 10 minutes

  4. Heart rate

    Time frame: 10 minutes

  5. Plasma nitrite levels

    Time frame: 10 minutes

  6. Plasma nitrate levels

    Time frame: 10 minutes

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Oliveira-Paula GH, Coeli-Lacchini FB, Ferezin LP, Ferreira GC, Pinheiro LC, Paula-Garcia WN, Garcia LV, Tanus-Santos JE, Lacchini R. Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability. Eur J Clin Pharmacol. 2021 Jun;77(6):869-877. doi: 10.1007/s00228-020-03059-9. Epub 2021 Jan 7. PubMed 33410970 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 26, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02442232
Lead sponsor
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Responsible party
Gustavo Henrique Oliveira de Paula (PhD student, University of Sao Paulo) — Principal investigator
First posted
May 13, 2015
Start date
Aug 2015
Primary completion
Dec 2015
Completion
May 2016
Last update
Aug 26, 2016
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2016. You cannot join it, but the record below documents what was studied.

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