An interventional study of MRE in Gastrointestinal Tract, sponsored by United States Army Research Institute of Environmental Medicine. Completed at 1 site in United States. Open to participants aged 18 Years to 62 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-04-16.
Sponsored by United States Army Research Institute of Environmental Medicine · Not applicable, Interventional, and Other
The objective of this study is to determine the impact of consuming MREs as the sole source of subsistence for 21 days on gut bacteria community composition and gut health. Up to 80 free-living adults will be randomized to consume their usual diet or only MREs for 21 consecutive days. MREs will be provided by the Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM). Fecal, urine and blood samples will be collected periodically before, during and after the intervention to measure gut barrier integrity, gut bacteria community composition, and markers of gut health, inflammation, and nutritional status.
United States Army Research Institute of Environmental Medicine is the lead sponsor of 67 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Usual diet
MRE consumption
Other: MRE
MRE consumption
Change in gut barrier integrity
Urine excretion of saccharide probes; circulating zonulin, intestinal fatty acid binding protein, claudin-3, lipopolysaccharide and GLP2 concentrations
Time frame: Baseline to 10 days, 21 days and 31 days
Change in gut microbiota composition
16S rRNA gene sequencing
Time frame: Baseline to 10 days, 21 days and 31 days
Change in C-reactive protein concentrations
Serum C-reactive protein
Time frame: Baseline to 10 days, 21 days and 31 days
Change in TNF-alpha concentrations
Serum TNF-alpha
Time frame: Baseline to 10 days, 21 days and 31 days
Change in interleukin-6 concentrations
Serum IL-6
Time frame: Baseline to 10 days, 21 days and 31 days
Change in lipopolysaccharide concentrations
Plasma LPS
Time frame: Baseline to 10 days, 21 days and 31 days
Change in iron status
Blood ferritin, soluble transferrin receptor, hemoglobin, hematocrit
Time frame: Baseline to 10 days, 21 days and 31 days
Change in vitamin D status
Blood 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone
Time frame: Baseline to 10 days, 21 days and 31 days
Change in B-vitamin status
Blood folate, vitamin B12, homocysteine
Time frame: Baseline to 10 days, 21 days and 31 days
Change in nutritional status
Blood prealbumin
Time frame: Baseline to 10 days, 21 days and 31 days
Change in calcium absorption
Urine calcium
Time frame: Baseline to 10 days, 21 days and 31 days
Change in zinc status
Blood zinc, zinc receptor expression
Time frame: Baseline to 10 days, 21 days and 31 days
This study is completed, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.
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United States Army Research Institute of Environmental Medicine