An observational study in Dyspnea, sponsored by Seoul National University Hospital. Completed at 1 site in Korea, Republic of. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-05-26.
Sponsored by Seoul National University Hospital · Observational
The purpose of this study is to observe transient dyspnea pattern after Gd-EOB-DTPA administration by obtaining continuous dynamic T1 weighted image data.
656 studies on the registry are indexed under Dyspnea; 153 are open to participants now.
This study's enrollment of 60 is below the median of 122 across 204 observational studies indexed under Dyspnea.
Browse Dyspnea studies →Seoul National University Hospital is the lead sponsor of 1,860 studies on the registry; 275 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients who are referred to MR unit for hepatocyte-specific contrast enhanced liver MRI using gadoxetic acid.
Exclusion Criteria:
Patients who are referred to MR unit for hepatocyte-specific contrast (gadoxetic acid) enhanced liver magnetic resonance imaging (MRI)
Drug: gadoxetic acid · Other: Magnetic resonance imaging (MRI)
standard dose of gadoxetic acid (0.025mmol/kg) intravenous administration
Also known as: eovist, primovist
Dynamic T1 weighted sequence consist of precontrast, arterial, portal, transitional and hepatobiliary phases. precontrast, arterial and portal phases (prior to contrast media injection to 60 seconds after contrast media injection) are obtained continuously in free-breathing state. Transitional and hepatobiliary phases are obtained in breath-hold state.
Number of Participants With Transient Dyspnea.
A sudden onset irregular breathing pattern after EOB administration, based on MRI k-space data (not participants' symptom). The k-space data was analyzed after the enrollment completion.
Time frame: during 3 minutes after contrast media administration
Duration of Transient Dyspnea in Participants With Transient Dyspnea.
The duration of transient dyspnea was analyzed based on the MRI k-space data, using a dedicated software. The analysis using the MRI k-space data was performed after the completion of enrollment.
Time frame: during 3 minutes after contrast media administration
Liver Stiffness Value
liver stiffness value from MR elastography using GRE and SE sequence which is a part of protocol. Both GRE and SE sequences are two different sequences for obtaining MR elastogrphy which measures the stiffness of the liver. The measured liver stiffness is known to be related to the degree of hepatic fibrosis and/or inflammation.
Time frame: in three days after MRI
April 2015 to October 2015, patients who are referred to Radiology unit in SNUH for liver MRI scan.
| Milestone | EOB-MRI |
|---|---|
| Started | 60 |
| Completed | 59 |
| Not completed | 1 |
A sudden onset irregular breathing pattern after EOB administration, based on MRI k-space data (not participants' symptom). The k-space data was analyzed after the enrollment completion.
| Participants | EOB-MRI |
|---|---|
| Number of Participants With Transient Dyspnea. | 23 |
The duration of transient dyspnea was analyzed based on the MRI k-space data, using a dedicated software. The analysis using the MRI k-space data was performed after the completion of enrollment.
| second | Observe1 |
|---|---|
| Duration of Transient Dyspnea in Participants With Transient Dyspnea. | 21.5 ± 13 |
liver stiffness value from MR elastography using GRE and SE sequence which is a part of protocol. Both GRE and SE sequences are two different sequences for obtaining MR elastogrphy which measures the stiffness of the liver. The measured liver stiffness is known to be related to the degree of hepatic fibrosis and/or inflammation.
| kPa | EOB-MRI |
|---|---|
| SE MRE | 3.87 ± 1.19 |
| GRE MRE | 3.76 ± 1.29 |
Collected over 1 hour after MRI completion. Non-serious events are listed at a 5% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| EOB-MRI | — | 0/60 (0%) | 0/60 (0%) |
| Age, Continuous(years) | Observe1 |
|---|---|
| Mean | 60.1 ± 11.3 |
| Sex: Female, Male(Participants) | Observe1 |
|---|---|
| Female | 25 |
| Male | 35 |
| Region of Enrollment(participants) | Observe1 |
|---|---|
| South Korea | 60 |
Plan to share: No
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This study is completed, as verified in May 2021. You cannot join it, but the record below documents what was studied.
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Seoul National University Hospital