A Phase 4 interventional study of Varilrix in Cartilage-hair Hypoplasia, sponsored by Helsinki University Central Hospital. Status unknown. Open to participants aged 12 Months and older. Per ClinicalTrials.gov, last updated 2019-10-22.
Sponsored by Helsinki University Central Hospital · Phase 4, Interventional, and Prevention
The investigatoris will carefully select cartilage-hair hypoplasia patients unexposed to varicella (VZV) and immunize patients in a controlled manner with VZV vaccine. Patients will be selected on the basis of disease severity and the degree of immunodeficiency (including CD4+ T-cell counts). Any potential complication of VZV immunization, such as rash, will be discussed with the patients/caregivers beforehand and acyclovir will be used to treat any VZV related symptoms, consistent with the current practices. The investigators will verify the development of immune response to vaccination by testing for VZV antibodies and cell-mediated immunity.
Helsinki University Central Hospital is the lead sponsor of 311 studies on the registry; 61 are open to participants now.
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Exclusion Criteria:
Selected CHH patients will be vaccinated against varicella with Varilrix, one dose of 0,5 ml subcutaneously. If no response is documented to the first dose, the second dose of 0,5 ml can be administered.
Biological: Varilrix
Vaccination against varicella in selected cartilage-hair hypoplasia patients
Also known as: ATC J07BK01
Humoral response to vaccination
Time frame: 4-6 weeks post-vaccination
Cell-mediated response to vaccination
Time frame: 4-6 wks post-vaccination
Number and severity of adverse events to vaccination
Time frame: 0-60 days
No study locations are listed for this record.
This study is status unknown, as verified in Oct 2019. You cannot join it, but the record below documents what was studied.
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