A Phase 4 interventional study of propofol and dexmedetomidine in Abnormal Respiratory Airway Resistance, sponsored by Cukurova University. Completed at 1 site in Turkey. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2015-12-10.
Sponsored by Cukurova University · Phase 4, Interventional, and Treatment
The aim of this study is to compare the effects of dexmedetomidine and propofol on pulmonary mechanics in intensive care patients.
The aim of this study is to compare the effects propofol and dexmedetomidine on pulmonary mechanics. Sixty patients mechanically ventilated in intensive care unit are included in this study. Patients are divided into two random groups, Group P (propofol) and Group D (dexmedetomidine). Propofol infusion 0.5-2 mg/kg/h is given to Group P patients and dexmedetomidine infusion 0.2-0.7 mcg/kg/h is given to Group D patients for sedation. Initial blood gas analysis, airway resistance (cmH2O/L/sec), positive end-expiratory pressure (PEEP, cmH20), frequency (breath/min), tidal volume (mL/min), minute volume (mL), peak airway pressure (cmH20), compliance (mL/cmH20), endtidal CO2 (mmHg), SvO2 (%) values are recorded. This parameters are evaluated with Drager Evita 4 ventilator and recorded on 5th,15th,30th,45th ve 60th minutes . Sedation is observed using Riker and Ramsey Sedation-Agitation Scale. Compliance of patients to mechanical ventilation is observed and recorded.
The primary outcome measures are airway resistance and peak airway pressure. Secondary outcome measure is sedation score.
Cukurova University is the lead sponsor of 247 studies on the registry; 50 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Propofol infusion 0.5-2 mg/kg/h for sedation in mechanically ventilated patients
Drug: propofol
dexmedetomidine infusion 0.2-0.7 mcg/kg/h for sedation in mechanically ventilated patients
Drug: dexmedetomidine
airway resistance
airway resistans measured by Evita 4 ventilator flow sensor
Time frame: 60 minutes
peak airway pressure values
peak airway pressure values provide the methods used to Evita 4 ventilator flow sensor
Time frame: 60 minutes
This study is completed, as verified in Dec 2015. You cannot join it, but the record below documents what was studied.
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Cukurova University