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CompletedNCT02309255Updated Jun 15, 2015

The NOR-COR Study for Coronary Prevention

An observational study in Secondary Coronary Prevention, sponsored by Vestre Viken Hospital Trust. Completed at 1 site in Norway. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-06-15.

Sponsored by Vestre Viken Hospital Trust · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
975
Ages
18 Years to 80 Years
Sex
All
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Study summary

The NOR-COR study is a cross-sectional, observational study designed to explore a large number of cardiovascular, inflammatory, genetic, behavioral, and psychosocial factors (including anxiety, depression, quality of life) in 1369 patients with established coronary heart disease (CHD) hospitalized in the Sections for Cardiology at the hospitals in Drammen (n=722) and Vestfold (n=647). Study data from an extensive questionnaire, clinical and laboratory data, and sputum/saliva for genetic analyses will be collected.

The main overall aim of the NOR-COR study is to develop new strategies to improve secondary prevention for underserved high risk patient-groups with CHD. The first study phase aims to collect information necessary to develop empirically based future secondary coronary prevention interventions. In a genetic sub-project markers associated with CHD and personality type will be explored.

The study will evaluate current secondary preventive programs and explore the mechanisms that link behavioral, psychosocial, inflammatory, and genetic factors to poor prognosis. The study will in short term provide new knowledge potentially useful for increasing participation in current cardiac rehabilitation/secondary preventive programs. For a longer perspective these associations may be useful for design of new intervention programs to selected high risk patient groups whom may be in need of programs with different content and/or of longer duration than those currently being applied.

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Conditions studied

  • Secondary Coronary Prevention

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Keywords

  • Secondary coronary prevention
  • Psychosocial factors
  • Cardiac rehabilitation
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In context

Neoplasm Metastasis

3,514 studies on the registry are indexed under Neoplasm Metastasis; 883 are open to participants now.

This study's enrollment of 975 is above the median of 121 across 593 observational studies indexed under Neoplasm Metastasis.

Browse Neoplasm Metastasis studies →

Lead sponsor

Vestre Viken Hospital Trust is the lead sponsor of 51 studies on the registry; 22 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

1365 CHD patients

Inclusion criteria

All patients aged 18-80 years with first or recurrent diagnosis or treatments for CHD: a) acute myocardial infarction [ICD-10; I21], b) coronary artery by-pass graft operation (CABG), or c) elective or emergency PCI [ICD-10; I25]) have been identified from hospital patient discharge lists (diagnostic lists) by searching chronologically after last admission the past three years. In patients with recurrent diagnosis the last event will define the event.

Exclusion criteria

Exclusion Criteria:

  • Cognitive impairment that would invalidate assessment including all patients living at nursing home and psychosis.
  • Short life expectancy (i.e. \<1 year) due to terminal heart (NYHA class 4), lung (chronic obstructive pulmonary disease GOLD 4)-, liver- or kidney disease (chronic kidney disease stage 5), malignant disease, or other reason.
  • Not able to understand and write the Norwegian language or refuse to give written informed consent to study participation.
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
975 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • coronary heart disease patients

    Other: no intervention

Interventions

  • Otherno intervention
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What researchers measure

Primary outcomes

  1. Cardiovascular risk factors, lifestyle, and drug adherence

    Time frame: Within 2 years after study inclusion

Secondary outcomes

  1. Readmission with a coronary event, acute myocardial infarctrion and cardiovascular mortality

    Time frame: Within 5 years after study inclusion

Other outcomes

  1. The hospital anxiety and depression scale (HADS)

    Time frame: Within 2 years after study inclusion

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Study locations

1 site
  • Vestre Viken HF, Drammen Hospital and The Hospital of Vestfold
    Drammen and Tønsberg, Buskerud and Vestfold N-3004, Norway
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References and documents

Publications

  • Sverre E, Peersen K, Perk J, Husebye E, Gullestad L, Dammen T, Otterstad JE, Munkhaugen J. Challenges in coronary heart disease prevention - experiences from a long-term follow-up study in Norway. Scand Cardiovasc J. 2021 Apr;55(2):73-81. doi: 10.1080/14017431.2020.1852308. Epub 2020 Dec 4. PubMed 33274648 ↗
  • Sverre E, Peersen K, Weedon-Fekjaer H, Perk J, Gjertsen E, Husebye E, Gullestad L, Dammen T, Otterstad JE, Munkhaugen J. Preventable clinical and psychosocial factors predicted two out of three recurrent cardiovascular events in a coronary population. BMC Cardiovasc Disord. 2020 Feb 5;20(1):61. doi: 10.1186/s12872-020-01368-6. PubMed 32024471 ↗
  • Munkhaugen J, Hjelmesaeth J, Otterstad JE, Helseth R, Sollid ST, Gjertsen E, Gullestad L, Perk J, Moum T, Husebye E, Dammen T. Managing patients with prediabetes and type 2 diabetes after coronary events: individual tailoring needed - a cross-sectional study. BMC Cardiovasc Disord. 2018 Aug 3;18(1):160. doi: 10.1186/s12872-018-0896-z. PubMed 30075751 ↗
  • Sverre E, Otterstad JE, Gjertsen E, Gullestad L, Husebye E, Dammen T, Moum T, Munkhaugen J. Medical and sociodemographic factors predict persistent smoking after coronary events. BMC Cardiovasc Disord. 2017 Sep 6;17(1):241. doi: 10.1186/s12872-017-0676-1. PubMed 28877684 ↗
  • Sverre E, Peersen K, Husebye E, Gjertsen E, Gullestad L, Moum T, Otterstad JE, Dammen T, Munkhaugen J. Unfavourable risk factor control after coronary events in routine clinical practice. BMC Cardiovasc Disord. 2017 Jan 21;17(1):40. doi: 10.1186/s12872-016-0387-z. PubMed 28109259 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 15, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02309255
Lead sponsor
Vestre Viken Hospital Trust
Collaborators
The Hospital of Vestfold, Oslo University Hospital, Kalmar County Hospital
Responsible party
Sponsor
First posted
Dec 5, 2014
Start date
Feb 2014
Primary completion
Apr 2015
Completion
Apr 2015
Last update
Jun 15, 2015

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2015. You cannot join it, but the record below documents what was studied.

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