An interventional study of Zingiberis Rhizoma plv. and Sinapis nigrea semen in Healthy, sponsored by ARCIM Institute Academic Research in Complementary and Integrative Medicine. Completed at 1 site in Germany. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-16.
Sponsored by ARCIM Institute Academic Research in Complementary and Integrative Medicine · Not applicable, Interventional, and Supportive care
In integrative medicine wraps are applied for different indications. In this study the effects of thorax with ginger and mustard flour are investigated under standardized conditions. Heart rate variability, well being, warmth distribution and respiratory activity of healthy subjects will be measured.
The purpose of this study is to investigate the effects of different thorax wraps in healthy subjects. Subjects undergo three different interventions (wraps with ginger flour, mustard flour or warm water (placebo)) on three different days. Heart rate variability and respiratory activity is measured for ten minutes before, during (up to 20 minutes) and for ten minutes after each thorax wrap. To investigate the effects on heat development and regulation, photos are taken with a thermographic infrared camera at various moments in time. Participants are asked to fill in questionnaires referring to their subjective perceptions of warmth, bodily warmth distribution and wellbeing. The order of the thorax wrap interventions is randomized.
Exclusion Criteria:
Inflectional disease with body temperature > 38 °C. Skin damage on the thorax area Known intolerance or hypersensitivity to mustard or ginger products. Heart failure. Asthma bronchiale. Taking medication with influence on heart rate variability ( mainly tricyclic antidepressants and beta blocker).
Consumption of coffee or nicotine less than three hours before the intervention.
Pregnancy. Deficient knowledge of the German language.
Thorax wrap with ginger flour, duration max. 20 minutes
Drug: Zingiberis Rhizoma plv.
Thorax wrap with mustard flour, duration max 20 minutes
Drug: Sinapis nigrea semen
Thorax wrap with warm water (placebo), duration: 20 minutes
Drug: Placebo
changes in temperature
Temperature (in °Celsius) of feet, lower legs, hands and face measured with a thermographic infrared camera (pre-post-comparison)
Time frame: max. 40 minutes
Respiratory activity (expiratory CO2 and NO-measurement)
Physiological parameters are measured for pre-post comparison.
Time frame: max. 40 minutes
Basler Mood Questionnaire (BBS)
filled in by the participants nine times (before and after the thorax wrap and 10 minutes after the intervention)
Time frame: 40 minutes
Herdecker Wärmeempfindungs-Fragebogen (HeWef)
filled in by the participants nine times (before and after the thorax wrap and 10 minutes after the intervention)
Time frame: 40 minutes
Warmth perception and skin irritation (NRS)
Warmth perception and skin irritation during the intervention every minute (measured with a numeric rating scale).
Time frame: 40 minutes
heart rate variability -Parameter (HRV)
Standard Deviation of Normal to Normal (heart rate) (SDNN)
Time frame: Physiological parameters are measured over a period of 40 minutes
heart rate variability -Parameter (HRV)
Root Mean Square of the Successive Differences (RMSSD)
Time frame: Physiological parameters are measured over a period of 40 minutes
heart rate variability -Parameter (HRV)
ratio low frequency to high frequency (LF/HF)
Time frame: Physiological parameters are measured over a period of 40 minutes
heart rate variability -Parameter (HRV)
very low frequency (VLF)
Time frame: Physiological parameters are measured over a period of 40 minutes
heart rate variability -Parameter (HRV)
NN50 (the number of pairs of successive NNs that differ by more than 50 ms)
Time frame: Physiological parameters are measured over a period of 40 minutes
This study is completed, as verified in May 2018. You cannot join it, but the record below documents what was studied.
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ARCIM Institute Academic Research in Complementary and Integrative Medicine