A Phase 4 interventional study of Sodium nitrate and Beetroot juice in Blood Pressure and Nutritional Physiological Phenomena, sponsored by Maastricht University Medical Center. Completed at 1 site in Netherlands. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-03-16.
Sponsored by Maastricht University Medical Center · Phase 4, Interventional, and Basic science
The main aim of the current study will be to compare the effects of ingesting different nitrate-rich sources on plasma nitrite concentrations.
Oral ingestion of nitrate (NO3-) has been shown to increase plasma nitrate and nitrite levels. Significant lowering of pulmonary oxygen uptake during exercise, as well as significantly lower blood pressure values at rest have been observed after supplementation with nitrate. However, no study has yet described a direct comparison between different nitrate-rich beverages with respect to the bioavailability of nitrate/nitrite and the possible hemodynamic effects. Based on the gaps in current literature, our main goal will therefore be to gain further insight into the effects of nitrate supplementation with different sources on plasma nitrite levels.
Maastricht University Medical Center is the lead sponsor of 835 studies on the registry; 122 are open to participants now.
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Exclusion Criteria:
Dietary supplement: 800 mg of nitrate in sodium nitrate added with water to get a 140 mL solution (BASF, Ludwigshafen, Germany)
Dietary Supplement: Beetroot juice · Dietary Supplement: Spinach · Dietary Supplement: Rocket salad
Dietary supplement: 800 mg of nitrate in concentrated beetroot juice (Beet-IT)
Dietary Supplement: Sodium nitrate · Dietary Supplement: Spinach · Dietary Supplement: Rocket salad
Dietary supplement: 800 mg of nitrate in a spinach based beverage
Dietary Supplement: Sodium nitrate · Dietary Supplement: Beetroot juice · Dietary Supplement: Rocket salad
Dietary supplement: 800 mg of nitrate in a rocket salad based beverage
Dietary Supplement: Sodium nitrate · Dietary Supplement: Beetroot juice · Dietary Supplement: Spinach
Plasma nitrite levels
Plasma nitrite levels following ingestion of dietary nitrate
Time frame: Baseline until 5 hours after ingestion
Plasma levels of nitrate
Plasma nitrate levels following ingestion of dietary nitrate
Time frame: Baseline until 5 hours post-ingestion
Resting blood pressure
Resting blood pressure measures following ingestion of dietary nitrate
Time frame: Baseline, 2.5 hours and 5 hours post-ingestion
Tongue scraping to assess bacterial mouth flora.
Tongue scraping to assess bacterial mouth flora.
Time frame: 5 h post-ingestion
Baseline characteristics
Resting blood pressure, height, body weight, age, BMI
Time frame: 1 hour during visit 1 (Screening)
This study is completed, as verified in May 2015. You cannot join it, but the record below documents what was studied.
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Maastricht University Medical Center